Shariq Ali, Tanvir Syed Bilal, Zaman Atif, Khan Salman, Anis Armeena, Khan Misha Aftab, Ahmed Sumaira
Department of Microbiology, Dr. Ziauddin, Medical University Hospital, Sindh, Karachi, Pakistan.
Department of Surgery, Dr. Ziauddin University Hospital, Karachi, Pakistan.
Int J Health Sci (Qassim). 2017 Jan-Mar;11(1):1-4.
To determine the resistance and sensitivity pattern of methicillin-resistant Staphylococcus aureus (MRSA) isolates to linezolid (LZD) along with its prevalence in a tertiary care hospital of Karachi, Pakistan.
A cross-sectional study was carried out. This study lasted for about 1 year. Prevalence and sensitivity of LZD, vancomycin, and oxacillin was tested against isolates of MRSA.
Out of total 369 specimens 165 were found to be MRSA making the prevalence in our study 44.7%. All of the isolates which were tested positive for MRSA were susceptible to LZD and no resistance was noted when compared with previous studies performed in Europe and USA.
Stringent implementation of infection control measures along with screening for resistance in patients on prolonged LZD therapy or who previously went under LZD therapy should be performed, coupled with judicious usage of the aforementioned antibiotic should be undertaken, as sufficient data is not available at this point for the clinical spectrum of LZD resistant S. aureus, antimicrobial resistance.
确定耐甲氧西林金黄色葡萄球菌（MRSA）分离株对利奈唑胺（LZD）的耐药性和敏感性模式及其在巴基斯坦卡拉奇一家三级护理医院中的流行情况。
进行了一项横断面研究。该研究持续了约1年。对MRSA分离株测试了LZD、万古霉素和苯唑西林的流行率和敏感性。
在总共369份标本中，发现165份为MRSA，使我们研究中的流行率为44.7%。所有MRSA检测呈阳性的分离株对LZD敏感，与欧洲和美国此前进行的研究相比，未发现耐药情况。
应严格实施感染控制措施，对接受长期LZD治疗或曾接受LZD治疗的患者进行耐药性筛查，并明智地使用上述抗生素，因为目前尚无足够数据了解耐LZD金黄色葡萄球菌的临床谱、抗菌药物耐药性。
