Truzzi Anna, Bornstein Marc H, Senese Vincenzo P, Shinohara Kazuyuki, Setoh Peipei, Esposito Gianluca
Department of Psychology and Cognitive Science, University of TrentoRovereto, Italy; Laboratory for Affiliative Social Behavior, Brain Science Institute, RIKENSaitama, Japan.
Child and Family Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development Bethesda, MD, USA.
Front Physiol. 2017 Feb 28;8:111. doi: 10.3389/fphys.2017.00111. eCollection 2017.
Adults' adaptive interactions with intimate partners enhance well-being. Here we hypothesized that adult males' physiological responses to opposite-sex conspecifics' distress result from an interaction between an environmental factor (early social interaction with caregivers) and a genetic factor (a polymorphism within the promoter region of the serotonin transporter gene, 5-HTTLPR). We assessed heart rate changes in 42 non-married male adults to distress vocalizations (female, infant, and bonobo cries). Males' early interaction with parents was assessed using the Parental Bonding Instrument. Buccal mucosa cell samples were collected to assess their 5-HTTLPR genotype. A significant interaction emerged between early experience and genetic predisposition. Males with a genetic predisposition for higher sensitivity to environmental factors showed atypical physiological responses to adult female cries according to their experienced early maternal parenting. Environmental experiences and genetic characteristics are associated with adult males' physiological responses to socially meaningfully stimuli. Understanding the mechanisms that modulate responses to opposite-sex conspecifics may improve personal well-being and social adaptiveness.
成年人与亲密伴侣的适应性互动能提升幸福感。在此，我们假设成年男性对异性同种个体痛苦的生理反应是由一个环境因素（与照料者的早期社会互动）和一个遗传因素（血清素转运体基因启动子区域内的一个多态性，5-HTTLPR）之间的相互作用导致的。我们评估了42名未婚成年男性对痛苦叫声（女性、婴儿和倭黑猩猩的哭声）的心率变化。使用父母养育方式问卷评估男性早期与父母的互动情况。采集颊黏膜细胞样本以评估他们的5-HTTLPR基因型。早期经历和遗传易感性之间出现了显著的相互作用。根据其早年经历的母亲养育方式，对环境因素具有较高敏感性遗传倾向的男性对成年女性哭声表现出非典型的生理反应。环境经历和遗传特征与成年男性对具有社会意义刺激的生理反应相关。了解调节对异性同种个体反应的机制可能会改善个人幸福感和社会适应性。
