可溶性肿瘤坏死因子受体水平：根尖周炎与冠心病的关联

sTNF-R Levels: Apical Periodontitis Linked to Coronary Heart Disease.

作者信息

Singhal Rajnish K, Rai Balwant

机构信息

Department of Conservative Dentistry and Endodontics, Maharana Pratap College of Dentistry and Research Centre, Gwalior (M.P), India.

World Dental Networks, Denmark, Chief, JBR Society, India; Director, KSI, USA.

出版信息

Open Access Maced J Med Sci. 2017 Mar 15;5(1):68-71. doi: 10.3889/oamjms.2017.010. Epub 2017 Jan 17.

DOI:10.3889/oamjms.2017.010

PMID:28293320

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5320911/

Abstract

BACKGROUND

Different studies have implicated the exposure to systemic conditions in the aetiology of cardiovascular diseases like chronic inflammation including chronic periodontitis.

AIM

The present study has been conducted to examine whether biomarker sTNF-R was elevated in apical periodontitis as sTNF-R is a systemic marker of inflammation and has been identified as risk factors for cardiovascular diseases.

MATERIAL AND METHODS

sTNF-R levels were measured in 52 patients with apical periodontitis (M:F::25:27), aged 20-45 years and in 20 control patients without periodontitis (M:F::10:10, aged 20-48 years). Measurement of sTNF-R1 and sTNF-R2 was carried out in duplicate with standardised, commercially available enzyme immunoassays (R&D Systems Europe, Abingdon, UK).

RESULTS

The mean sTNF-R1 and sTNF-R2 levels in periodontitis were 820 (240) pg/ml (413 - 1620 pg/ml) and 1309 (403) pg/ml (540 - 2430 pg/ml), while in normal sTNF-R1 and sTNF - R2 levels were 740 (340) pg/ml (407-1240 pg/ml) and 1283 (414) pg (480 - 2340 pg/ml) respectively. Results indicated a positive high relationship between cardiovascular markers such as sTNF-R1 and sTNF - R2 and apical periodontitis.

CONCLUSION

Elevated levels of sTNF-R1 and sTNF - R2 in apical periodontitis patients indicate an increased independent risk of coronary heart disease.

摘要

背景

不同研究表明，接触全身性疾病如包括慢性牙周炎在内的慢性炎症是心血管疾病病因之一。

目的

本研究旨在探讨可溶性肿瘤坏死因子受体（sTNF-R）在根尖周炎中是否升高，因为sTNF-R是一种全身性炎症标志物，且已被确定为心血管疾病的危险因素。

材料与方法

对52例年龄在20 - 45岁的根尖周炎患者（男:女::25:27）和20例无牙周炎的对照患者（男:女::10:10，年龄20 - 48岁）进行sTNF-R水平检测。采用标准化的市售酶免疫分析法（英国阿宾顿的R&D Systems Europe公司）对sTNF-R1和sTNF-R2进行重复测量。

结果

牙周炎患者中sTNF-R1和sTNF-R2的平均水平分别为820（240）pg/ml（413 - 1620 pg/ml）和1309（403）pg/ml（540 - 2430 pg/ml），而正常对照组中sTNF-R1和sTNF-R2的水平分别为740（340）pg/ml（407 - 1240 pg/ml）和1283（414）pg/ml（480 - 2340 pg/ml）。结果表明，sTNF-R1和sTNF-R2等心血管标志物与根尖周炎之间存在高度正相关。