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Myositis-specific and myositis-associated autoantibody profiles and their clinical associations in a large series of patients with polymyositis and dermatomyositis.在一组大型多发性肌炎和皮肌炎患者中，肌炎特异性和肌炎相关性自身抗体谱及其与临床的相关性。
Clinics (Sao Paulo). 2013 Jul;68(7):909-14. doi: 10.6061/clinics/2013(07)04.
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Clinical manifestations and outcome of anti-PL7 positive patients with antisynthetase syndrome.抗合成酶综合征伴抗-PL7 阳性患者的临床表现和转归。
Eur J Intern Med. 2013 Jul;24(5):474-9. doi: 10.1016/j.ejim.2013.01.002. Epub 2013 Feb 1.
3
Inflammatory myopathies with anti-Ku antibodies: a prognosis dependent on associated lung disease.伴有抗Ku抗体的炎性肌病：预后取决于相关肺部疾病。
Medicine (Baltimore). 2012 Mar;91(2):95-102. doi: 10.1097/MD.0b013e31824d9cec.
4
Myositis-related interstitial lung disease and antisynthetase syndrome.肌炎相关性间质性肺病和抗合成酶综合征。
J Bras Pneumol. 2011 Jan-Feb;37(1):100-9. doi: 10.1590/s1806-37132011000100015.
5
Autoantibodies and their significance in myositis.自身抗体及其在肌炎中的意义。
Curr Rheumatol Rep. 2008 Aug;10(4):333-40. doi: 10.1007/s11926-008-0053-2.
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Autoantibodies in idiopathic inflammatory myopathy: an update on clinical and pathophysiological significance.特发性炎性肌病中的自身抗体：临床及病理生理意义的最新进展
Curr Opin Rheumatol. 2007 Nov;19(6):523-9. doi: 10.1097/BOR.0b013e3282f01a8c.
7
Heterogeneity of autoantibodies in 100 patients with autoimmune myositis: insights into clinical features and outcomes.100例自身免疫性肌炎患者自身抗体的异质性：对临床特征和结局的见解
Arthritis Res Ther. 2007;9(4):R78. doi: 10.1186/ar2276.
8
In patients with antisynthetase syndrome the occurrence of anti-Ro/SSA antibodies causes a more severe interstitial lung disease.在抗合成酶综合征患者中，抗Ro/SSA抗体的出现会导致更严重的间质性肺病。
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9
Clinical implications of autoantibody screening in patients with autoimmune myositis.自身免疫性肌炎患者自身抗体筛查的临床意义
Autoimmunity. 2006 May;39(3):217-21. doi: 10.1080/08916930600622645.
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[Digital necrosis disclosing antisynthetase syndrome].[数字坏死揭示抗合成酶综合征]
Ann Dermatol Venereol. 1994;121(6-7):493-5.

急性手指缺血：抗合成酶综合征的一种罕见表现。

Acute digital ischemia: A rare presentation of antisynthetase syndrome.

作者信息

Chan Jin Ei, Palakodeti Sandeep, Koster Matthew J

机构信息

Department of Medicine, Fudan University Shanghai Medical College, Shanghai, China.

Division of Hospital Internal Medicine, Department of Internal Medicine, Mayo Clinic College of Medicine and Science, Minnesota, USA.

出版信息

Eur J Rheumatol. 2017 Mar;4(1):63-65. doi: 10.5152/eurjrheum.2017.16077. Epub 2017 Mar 1.

DOI:10.5152/eurjrheum.2017.16077
PMID:28293456
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5335890/
Abstract

Antisynthetase syndrome (ASS) is recognized as a subgroup of idiopathic inflammatory myopathies (IIMs). It is associated with autoantibodies directed against aminoacyl-transfer ribonucleic acid (tRNA) synthetase enzymes. We report the first case of anti-PL-7/anti-SSA 52kD ASS presenting as acute digital ischemia, an association not described previously. Occlusive vasculopathy is a rare but serious manifestation that can be seen at presentation in patients with ASS and may herald the onset of severe interstitial lung disease (ILD). Comprehensive evaluation should be performed to confirm the presence of subclinical myositis. Extensive myositis-specific antibody testing is strongly recommended even if initial screening autoimmune serologies are unrevealing.

摘要

抗合成酶综合征（ASS）被认为是特发性炎性肌病（IIM）的一个亚组。它与针对氨酰基转移核糖核酸（tRNA）合成酶的自身抗体有关。我们报告了首例以急性指端缺血为表现的抗PL - 7/抗SSA 52kD抗合成酶综合征，此前未见这种关联的描述。闭塞性血管病是一种罕见但严重的表现，可见于抗合成酶综合征患者的初发症状中，可能预示着严重间质性肺病（ILD）的发作。应进行全面评估以确认亚临床肌炎的存在。即使初始筛查自身免疫血清学检查未发现异常，也强烈建议进行广泛的肌炎特异性抗体检测。