Disdier P, Bolla G, Harle J R, Pache X, Weiller-Merli C, Marco M S, Figarella-Branger D, Weiller P J
Service de Médecine Interne, Hôpital de la Timone, Marseille.
Ann Dermatol Venereol. 1994;121(6-7):493-5.
The antisynthetases syndrome associates lung disease, polymyositis, Raynaud's phenomenon and frequently polyarthritis. Anti-amioacyl-tRNA synthetase antibodies are present. The most common is anti-Jol. We report a case with severe arteritis of the finger with multiple zones of skin necrosis which responded favourably to corticosteroids given in bolus and cyclophosphamid. Finger arteritis, in addition to classical Raynaud's phenomenon, may be a new manifestation of the anti-synthetases syndrome.
抗合成酶综合征常伴有肺部疾病、多发性肌炎、雷诺现象，且常出现多关节炎。存在抗氨酰 - tRNA合成酶抗体。最常见的是抗Jo-1抗体。我们报告一例患有手指严重动脉炎并伴有多个皮肤坏死区域的病例，该病例对大剂量给予的皮质类固醇和环磷酰胺反应良好。除了典型的雷诺现象外，手指动脉炎可能是抗合成酶综合征的一种新表现。
