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孕期使用阿那白滞素：一例伴有家族性地中海热和不孕症的病例报告。

Anakinra use during pregnancy: Report of a case with Familial Mediterranean Fever and infertility.

作者信息

İlgen Ufuk, Küçükşahin Orhan

机构信息

Department of Internal Medicine, Ankara University School of Medicine, İbn-i Sina Hospital, Ankara, Turkey.

Department of Rheumatology, Yıldırım Beyazıt University Medical School, Atatürk Research and Training Hospital, Ankara, Turkey.

出版信息

Eur J Rheumatol. 2017 Mar;4(1):66-67. doi: 10.5152/eurjrheum.2017.16075. Epub 2017 Mar 1.

DOI:10.5152/eurjrheum.2017.16075
PMID:28293457
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5335891/
Abstract

Familial Mediterranean fever (FMF), affecting people of Mediterranean origin, is an endemic and sometimes problematic disease because of colchicine resistance/intolerance, with relative lack of treatment alternatives, and disease- or treatment-related issues, such as subfertility. Anakinra, being a rational and effective treatment alternative, has no conclusive human pregnancy data. Here we report a case of FMF with infertility who became pregnant with in vitro fertilization (IVF) under treatment with anakinra, along with the pregnancy outcome.

摘要

家族性地中海热（FMF）影响地中海地区血统的人群，是一种地方性疾病，有时会成为难题，因为存在秋水仙碱耐药/不耐受情况，治疗选择相对较少，且存在与疾病或治疗相关的问题，如生育力低下。阿那白滞素作为一种合理且有效的治疗选择，尚无确凿的人类妊娠数据。在此，我们报告一例患有不育症的FMF患者，在接受阿那白滞素治疗期间通过体外受精（IVF）成功怀孕，并报告了妊娠结局。

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本文引用的文献

1
Anakinra use during pregnancy in patients with cryopyrin-associated periodic syndromes (CAPS).妊娠期使用阿那白滞素治疗冷吡啉相关周期性综合征（CAPS）。
Arthritis Rheumatol. 2014 Nov;66(11):3227-32. doi: 10.1002/art.38811.
2
The interplay of the interleukin 1 system in pregnancy and labor.白细胞介素 1 系统在妊娠和分娩中的相互作用。
Reprod Sci. 2014 Jan;21(1):122-30. doi: 10.1177/1933719113492204. Epub 2013 Jun 7.
3
The role of interleukin-1β in human trophoblast motility.白细胞介素-1β在人滋养层细胞运动中的作用。
Placenta. 2012 Sep;33(9):696-703. doi: 10.1016/j.placenta.2012.05.008. Epub 2012 Jun 17.
4
Second trimester maternal plasma levels of cytokines IL-1Ra, Il-6 and IL-10 and preterm birth.中孕期母体外周血细胞因子 IL-1Ra、IL-6 和 IL-10 水平与早产的关系。
J Perinatol. 2012 Jul;32(7):483-90. doi: 10.1038/jp.2011.193. Epub 2012 Mar 29.
5
Early detection of placental inflammation by MRI enabling protection by clinically relevant IL-1Ra administration.通过 MRI 早期检测胎盘炎症，从而通过临床相关的 IL-1Ra 给药进行保护。
Am J Obstet Gynecol. 2012 Apr;206(4):358.e1-9. doi: 10.1016/j.ajog.2012.01.008. Epub 2012 Jan 13.
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Successful outcome of two pregnancies in patients with adult-onset Still's disease treated with IL-1 receptor antagonist (anakinra).两例接受白细胞介素-1 受体拮抗剂（阿那白滞素）治疗的成人Still 病患者妊娠结局成功。
Clin Exp Rheumatol. 2011 Nov-Dec;29(6):1021-3. Epub 2011 Dec 22.
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A patient's wish: anakinra in pregnancy.一位患者的愿望：孕期使用阿那白滞素。
Ann Rheum Dis. 2009 Nov;68(11):1794-5. doi: 10.1136/ard.2008.105833.
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Familial Mediterranean fever and its implications for fertility and pregnancy.家族性地中海热及其对生育和妊娠的影响。
Eur J Obstet Gynecol Reprod Biol. 2003 Jun 10;108(2):171-6. doi: 10.1016/s0301-2115(02)00417-7.