孕期使用阿那白滞素：一例伴有家族性地中海热和不孕症的病例报告。
Anakinra use during pregnancy: Report of a case with Familial Mediterranean Fever and infertility.
作者信息
İlgen Ufuk, Küçükşahin Orhan
机构信息
Department of Internal Medicine, Ankara University School of Medicine, İbn-i Sina Hospital, Ankara, Turkey.
Department of Rheumatology, Yıldırım Beyazıt University Medical School, Atatürk Research and Training Hospital, Ankara, Turkey.
出版信息
Eur J Rheumatol. 2017 Mar;4(1):66-67. doi: 10.5152/eurjrheum.2017.16075. Epub 2017 Mar 1.
Abstract
Familial Mediterranean fever (FMF), affecting people of Mediterranean origin, is an endemic and sometimes problematic disease because of colchicine resistance/intolerance, with relative lack of treatment alternatives, and disease- or treatment-related issues, such as subfertility. Anakinra, being a rational and effective treatment alternative, has no conclusive human pregnancy data. Here we report a case of FMF with infertility who became pregnant with in vitro fertilization (IVF) under treatment with anakinra, along with the pregnancy outcome.
摘要
家族性地中海热（FMF）影响地中海地区血统的人群，是一种地方性疾病，有时会成为难题，因为存在秋水仙碱耐药/不耐受情况，治疗选择相对较少，且存在与疾病或治疗相关的问题，如生育力低下。阿那白滞素作为一种合理且有效的治疗选择，尚无确凿的人类妊娠数据。在此，我们报告一例患有不育症的FMF患者，在接受阿那白滞素治疗期间通过体外受精（IVF）成功怀孕，并报告了妊娠结局。
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