孕期使用阿那白滞素：一例伴有家族性地中海热和不孕症的病例报告。
Anakinra use during pregnancy: Report of a case with Familial Mediterranean Fever and infertility.
作者信息
İlgen Ufuk, Küçükşahin Orhan
机构信息
Department of Internal Medicine, Ankara University School of Medicine, İbn-i Sina Hospital, Ankara, Turkey.
Department of Rheumatology, Yıldırım Beyazıt University Medical School, Atatürk Research and Training Hospital, Ankara, Turkey.
出版信息
Eur J Rheumatol. 2017 Mar;4(1):66-67. doi: 10.5152/eurjrheum.2017.16075. Epub 2017 Mar 1.
Abstract
Familial Mediterranean fever (FMF), affecting people of Mediterranean origin, is an endemic and sometimes problematic disease because of colchicine resistance/intolerance, with relative lack of treatment alternatives, and disease- or treatment-related issues, such as subfertility. Anakinra, being a rational and effective treatment alternative, has no conclusive human pregnancy data. Here we report a case of FMF with infertility who became pregnant with in vitro fertilization (IVF) under treatment with anakinra, along with the pregnancy outcome.
摘要
家族性地中海热（FMF）影响地中海地区血统的人群，是一种地方性疾病，有时会成为难题，因为存在秋水仙碱耐药/不耐受情况，治疗选择相对较少，且存在与疾病或治疗相关的问题，如生育力低下。阿那白滞素作为一种合理且有效的治疗选择，尚无确凿的人类妊娠数据。在此，我们报告一例患有不育症的FMF患者，在接受阿那白滞素治疗期间通过体外受精（IVF）成功怀孕，并报告了妊娠结局。
相似文献
1
Anakinra use during pregnancy: Report of a case with Familial Mediterranean Fever and infertility.
Eur J Rheumatol. 2017 Mar;4(1):66-67. doi: 10.5152/eurjrheum.2017.16075. Epub 2017 Mar 1.
2
[IL-1-blockade with Anakinra during pregnancy : Retrospective analysis of efficacy and safety in female patients with familial Mediterranean fever].
Z Rheumatol. 2018 Mar;77(2):127-134. doi: 10.1007/s00393-017-0354-9.
3
Colchicine failure in familial Mediterranean fever and potential alternatives: embarking on the anakinra trial.
Isr Med Assoc J. 2014 May;16(5):271-3.
4
Anakinra induces complete remission of nephrotic syndrome in a patient with familial mediterranean fever and amyloidosis.
Nefrologia. 2016;36(1):63-6. doi: 10.1016/j.nefro.2015.06.026. Epub 2015 Sep 26.
5
Approach to the patients with inadequate response to colchicine in familial Mediterranean fever.
Best Pract Res Clin Rheumatol. 2016 Apr;30(2):296-303. doi: 10.1016/j.berh.2016.09.001. Epub 2016 Sep 21.
6
The efficacy of anakinra in an adolescent with colchicine-resistant familial Mediterranean fever.
Eur J Pediatr. 2008 Jun;167(6):695-6. doi: 10.1007/s00431-007-0547-3. Epub 2007 Jun 23.
7
Efficacy and safety of interleukin-1 inhibitors in familial Mediterranean fever patients complicated with amyloidosis.
Mod Rheumatol. 2019 Mar;29(2):363-366. doi: 10.1080/14397595.2018.1457469. Epub 2018 Apr 27.
8
Familial Mediterranean fever and its implications for fertility and pregnancy.
Eur J Obstet Gynecol Reprod Biol. 2003 Jun 10;108(2):171-6. doi: 10.1016/s0301-2115(02)00417-7.
9
Anti-interleukin-1 treatment in 26 patients with refractory familial mediterranean fever.
Mod Rheumatol. 2017 Mar;27(2):350-355. doi: 10.1080/14397595.2016.1194510. Epub 2016 Jun 22.
10
Successful treatment of familial Mediterranean fever with Anakinra and outcome after renal transplantation.
Nephrol Dial Transplant. 2009 Feb;24(2):676-8. doi: 10.1093/ndt/gfn646. Epub 2008 Nov 25.
引用本文的文献
1
Efficacy and Safety of Anakinra in Colchicine-Resistant or -Intolerant Familial Mediterranean Fever: A Single-Center Real-Life Experience.
Medicina (Kaunas). 2025 Apr 25;61(5):792. doi: 10.3390/medicina61050792.
2
Fertility in male patients with familial Mediterranean fever and paternal effect of FMF on pregnancy outcomes and complications.
Intern Emerg Med. 2025 Apr;20(3):797-803. doi: 10.1007/s11739-025-03881-y. Epub 2025 Feb 5.
3
Haemophagocytic lymphohistiocytosis in pregnancy and the postpartum period: A retrospective case series analysis.
NIHR Open Res. 2023 Mar 2;3:12. doi: 10.3310/nihropenres.13339.1. eCollection 2023.
4
An Update on Familial Mediterranean Fever.
Int J Mol Sci. 2023 May 31;24(11):9584. doi: 10.3390/ijms24119584.
5
COVID-19 Pharmacotherapy in Pregnancy: A Literature Review of Current Therapeutic Choices.
Viruses. 2023 Mar 19;15(3):787. doi: 10.3390/v15030787.
6
Hemophagocytic lymphohistiocytosis in pregnancy evolving towards fulminant hepatitis.
Obstet Med. 2022 Sep;15(3):208-211. doi: 10.1177/1753495X21999914. Epub 2021 Mar 24.
7
Haemophagocytic lymphohistiocytosis in pregnancy.
Obstet Med. 2022 Jun;15(2):79-90. doi: 10.1177/1753495X211011913. Epub 2021 Sep 26.
8
The Preferential Use of Anakinra in Various Settings of FMF: A Review Applied to an Updated Treatment-Related Perspective of the Disease.
Int J Mol Sci. 2022 Apr 2;23(7):3956. doi: 10.3390/ijms23073956.
9
Emerging Therapies for Recurrent Pericarditis: Interleukin-1 inhibitors.
J Am Heart Assoc. 2021 Oct 5;10(19):e021685. doi: 10.1161/JAHA.121.021685. Epub 2021 Sep 25.
10
Inflammasome Targeted Therapy in Pregnancy: New Insights From an Analysis of Real-World Data From the FAERS Database and a Systematic Review.
Front Pharmacol. 2021 Jan 20;11:612259. doi: 10.3389/fphar.2020.612259. eCollection 2020.
本文引用的文献
1
Anakinra use during pregnancy in patients with cryopyrin-associated periodic syndromes (CAPS).
Arthritis Rheumatol. 2014 Nov;66(11):3227-32. doi: 10.1002/art.38811.
2
The interplay of the interleukin 1 system in pregnancy and labor.
Reprod Sci. 2014 Jan;21(1):122-30. doi: 10.1177/1933719113492204. Epub 2013 Jun 7.
3
The role of interleukin-1β in human trophoblast motility.
Placenta. 2012 Sep;33(9):696-703. doi: 10.1016/j.placenta.2012.05.008. Epub 2012 Jun 17.
4
Second trimester maternal plasma levels of cytokines IL-1Ra, Il-6 and IL-10 and preterm birth.
J Perinatol. 2012 Jul;32(7):483-90. doi: 10.1038/jp.2011.193. Epub 2012 Mar 29.
5
Early detection of placental inflammation by MRI enabling protection by clinically relevant IL-1Ra administration.
Am J Obstet Gynecol. 2012 Apr;206(4):358.e1-9. doi: 10.1016/j.ajog.2012.01.008. Epub 2012 Jan 13.
6
Successful outcome of two pregnancies in patients with adult-onset Still's disease treated with IL-1 receptor antagonist (anakinra).
Clin Exp Rheumatol. 2011 Nov-Dec;29(6):1021-3. Epub 2011 Dec 22.
7
A patient's wish: anakinra in pregnancy.
Ann Rheum Dis. 2009 Nov;68(11):1794-5. doi: 10.1136/ard.2008.105833.
8
Familial Mediterranean fever and its implications for fertility and pregnancy.
Eur J Obstet Gynecol Reprod Biol. 2003 Jun 10;108(2):171-6. doi: 10.1016/s0301-2115(02)00417-7.
Zotero 插件