Donmez Oya, Kilinc Hilal, Ozbek Zeynep, Saatci Ali Osman
Specialist, Department of Ophthalmology, TC Hitit University, Izmir, Turkey.
Resident, Department of Ophthalmology, Dokuz Eylul University, Izmir, Turkey.
Med Hypothesis Discov Innov Ophthalmol. 2016 Winter;5(4):121-124.
We describe a 66-year-old man who developed bilateral choroidal detachment that was induced by unilateral topical administration of a fixed combination of 1% brinzolamide and 0.5% timolol maleate the day after an uneventful phacoemulsification surgery and intraocular lens implantation involving his right eye. We believe that the reaction was an idiosyncratic reaction, most likely against brinzolamide. The condition improved rapidly after the cessation of the fixed combination of brinzolamide and timolol maleate and treatment with 1% topical prednisolone acetate every hour and 1% cyclopentolate twice a day bilaterally. Although there are several similar cases involving choroidal detachment after oral acetazolamide and topical dorzolamide treatment mentioned in the literature, the present case is the first case report involving bilateral choroidal detachment after topical treatment with brinzolamide.
我们描述了一名66岁男性，在其右眼进行了顺利的白内障超声乳化手术和人工晶状体植入术后第二天，单侧局部应用1%布林佐胺和0.5%马来酸噻吗洛尔的固定组合后，发生了双侧脉络膜脱离。我们认为该反应是一种特异反应，最有可能是针对布林佐胺的。在停用布林佐胺和马来酸噻吗洛尔的固定组合，并双侧每小时局部应用1%醋酸泼尼松龙、每天两次应用1%环喷托酯治疗后，病情迅速改善。尽管文献中提到了几例口服乙酰唑胺和局部应用多佐胺治疗后发生脉络膜脱离的类似病例，但本病例是第一例关于局部应用布林佐胺后发生双侧脉络膜脱离的病例报告。
