Krenzien Felix, Krezdorn Nicco, Morgül Mehmet H, Wiltberger Georg, Atanasov Georgi, Hau Hans-Michael, Hinz Andreas, Schmelzle Moritz, Bartels Michael, Benzing Christian
Department of Surgery, Campus Charité-Mitte and Campus Virchow-Klinikum, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Berlin Institute of Health (BIH), Berlin,Germany.
Z Gastroenterol. 2017 Jun;55(6):557-563. doi: 10.1055/s-0043-102580. Epub 2017 Mar 14.
Older patients are neglected in clinical trials and are likely to be excluded from liver transplantation (LT). The aim of this study was to assess fatigue, anxiety, depression, and health-related quality of life (HRQoL) in elderly LT recipients. Questionnaires were mailed to patients who underwent LT between 1993 and 2013. Three groups were created: patients ≥ 70, 60 - 69, and < 60 years old. Mental-health status, life satisfaction, and fatigue were assessed using, respectively, the Hospital Anxiety and Depression Scale (HADS), Questions on Life Satisfaction (FLZ-M), and the Multidimensional Fatigue Inventory (MFI-20). In total, 276 eligible questionnaires (40.1 %) were received out of 689 patients with a history of LT. No age-related differences were found with regard to anxiety or depression in the study sample. Patients ≥ 70 years old had significantly better life satisfaction in regards to income (p = 0.003) and work (p = 0.005) compared to patients < 60 years. The overall fatigue scores were the highest in patients < 60 years (52.7, SD = 15.8) and ≥ 70 years (52.7, SD = 17.7) compared to patients 60 - 69 years old (48.2, SD = 17.3, p = 0.037). Advanced age alone should not be considered a contraindication for LT due to potentially poor quality of life outcomes.
老年患者在临床试验中被忽视，并且很可能被排除在肝移植（LT）之外。本研究的目的是评估老年LT受者的疲劳、焦虑、抑郁及健康相关生活质量（HRQoL）。向1993年至2013年间接受LT的患者邮寄了调查问卷。分为三组：年龄≥70岁、60 - 69岁和<60岁的患者。分别使用医院焦虑抑郁量表（HADS）、生活满意度问卷（FLZ-M）和多维疲劳量表（MFI-20）评估心理健康状况、生活满意度和疲劳程度。在689例有LT病史的患者中，共收到276份合格问卷（40.1%）。研究样本中未发现焦虑或抑郁方面的年龄差异。与<60岁的患者相比，≥70岁的患者在收入（p = 0.003）和工作（p = 0.005）方面生活满意度显著更高。与60 - 69岁的患者（48.2，标准差 = 17.3，p = 0.037）相比，<60岁（52.7，标准差 = 15.8）和≥70岁（52.7，标准差 = 17.7）的患者总体疲劳得分最高。不应仅因可能导致生活质量较差而将高龄视为LT的禁忌证。
