Department of Pharmacology, Faculty of Pharmacy,University of Seville,Seville,Spain.
Nutr Res Rev. 2017 Jun;30(1):118-137. doi: 10.1017/S0954422417000026. Epub 2017 Mar 15.
Systemic lupus erythematosus (SLE) is a chronic inflammatory and autoimmune disease characterised by multiple organ involvement and a large number of complications. SLE management remains complicated owing to the biological heterogeneity between patients and the lack of safe and specific targeted therapies. There is evidence that dietary factors can contribute to the geoepidemiology of autoimmune diseases such as SLE. Thus, diet therapy could be a promising approach in SLE owing to both its potential prophylactic effects, without the side effects of classical pharmacology, and its contribution to reducing co-morbidities and improving quality of life in patients with SLE. However, the question arises as to whether nutrients could ameliorate or exacerbate SLE and how they could modulate inflammation and immune function at a molecular level. The present review summarises preclinical and clinical experiences to provide the reader with an update of the positive and negative aspects of macro- and micronutrients and other nutritional factors, including dietary phenols, on SLE, focusing on the mechanisms of action involved.
系统性红斑狼疮（SLE）是一种慢性炎症性和自身免疫性疾病，其特征是多器官受累和大量并发症。由于患者之间的生物学异质性以及缺乏安全和特异的靶向治疗，SLE 的管理仍然很复杂。有证据表明，饮食因素可能促成自身免疫性疾病（如 SLE）的地理流行病学。因此，由于饮食疗法具有潜在的预防作用（没有经典药理学的副作用），并且有助于减少合并症并提高 SLE 患者的生活质量，因此它可能是 SLE 的一种有前途的治疗方法。然而，问题是营养素是否可以改善或加重 SLE，以及它们如何在分子水平上调节炎症和免疫功能。本文综述了临床前和临床经验，为读者提供了关于宏观和微观营养素以及其他营养因素（包括饮食中的酚类化合物）对 SLE 的积极和消极方面的最新信息，重点介绍了涉及的作用机制。
