Wolter Nikolaus E, Adil Eelam, Irace Alexandria L, Werger Annette, Perez-Atayde Antonio R, Weldon Christopher, Orbach Darren B, Rodriguez-Galindo Carlos, Rahbar Reza
Department of Otolaryngology and Communication Enhancement, Boston Children's Hospital, Boston, Massachusetts, U.S.A.
Department of Otolaryngology, Harvard Medical School, Boston, Massachusetts, U.S.A.
Laryngoscope. 2017 Dec;127(12):2873-2882. doi: 10.1002/lary.26550. Epub 2017 Mar 14.
OBJECTIVES/HYPOTHESIS: To describe our current multidisciplinary approach to pediatric malignant glomus tumors of the head and neck and review the current literature.
Retrospective chart review at a tertiary referral children's hospital and a comprehensive literature review.
A comprehensive literature search of PubMed, Embase, Web of Science, Google Scholar, and EBSCO with respect to malignant glomus tumors of the head and neck was conducted. We obtained expert input from other pertinent specialties, including oncology, pathology, and radiology. To highlight the difficulty of evaluation and management of these patients, we also present a pediatric patient with a left neck malignant glomus tumor and lung metastases.
Only two cases of pediatric malignant glomus tumor (including our own) have been reported in the English literature. Overall, 14 malignant glomus tumors have been reported in the head and neck (11 primary and three metastatic). Surgical resection is the mainstay of treatment, but local recurrence is common (five of 11, 45%).
Malignant glomus tumor of the head and neck is an extremely rare tumor in children. Evaluation consists of imaging, and tissue biopsy is necessary for definitive diagnosis. Management options include surgical resection with or without an adjuvant chemotherapy protocol similar to those designed for sarcoma. Additional reports are necessary so that we may determine the utility, if any, of radiotherapy in the management of this tumor. Laryngoscope, 127:2873-2882, 2017.
目的/假设：描述我们目前对头颈部小儿恶性血管球瘤的多学科治疗方法，并回顾当前文献。
在一家三级转诊儿童医院进行回顾性病历审查，并进行全面的文献综述。
对PubMed、Embase、科学网、谷歌学术和EBSCO进行了关于头颈部恶性血管球瘤的全面文献检索。我们从其他相关专业，包括肿瘤学、病理学和放射学，获得了专家意见。为了突出评估和治疗这些患者的困难，我们还展示了一名患有左侧颈部恶性血管球瘤和肺转移的儿科患者。
英文文献中仅报道了两例小儿恶性血管球瘤（包括我们自己的病例）。总体而言，头颈部已报道了14例恶性血管球瘤（11例原发性和3例转移性）。手术切除是主要治疗方法，但局部复发很常见（11例中有5例，45%）。
头颈部恶性血管球瘤在儿童中是一种极其罕见的肿瘤。评估包括影像学检查，明确诊断需要组织活检。治疗选择包括手术切除，可联合或不联合类似于肉瘤治疗方案的辅助化疗。需要更多的报道，以便我们确定放疗在该肿瘤治疗中的作用（如果有）。《喉镜》，2017年，第127卷：2873 - 2882页。
