经颅直流电刺激调节帕金森病患者的风险决策
Modulating risky decision-making in Parkinson's disease by transcranial direct current stimulation.
作者信息
Benussi A, Alberici A, Cantoni V, Manenti R, Brambilla M, Dell'Era V, Gazzina S, Manes M, Cristillo V, Padovani A, Cotelli M, Borroni B
机构信息
Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.
出版信息
Eur J Neurol. 2017 May;24(5):751-754. doi: 10.1111/ene.13286. Epub 2017 Mar 15.
BACKGROUND AND PURPOSE
Performance on gambling tasks in Parkinson's disease (PD) is of particular interest, as pathological gambling is often associated with dopamine replacement therapy in these patients. We aimed to evaluate the effects of transcranial direct current stimulation (tDCS) over the right dorsolateral prefrontal cortex (DLPFC) in modulating gambling behaviour in PD.
METHODS
We assessed the effects of cathodal tDCS over the right DLPFC during the Iowa Gambling Task in 20 patients with PD, compared with sham stimulation. We then conducted a second experimental design, assessing the effects of anodal tDCS over the right DLPFC.
RESULTS
We observed that cathodal tDCS over the right DLPFC increased Iowa Gambling Task scores compared with sham stimulation. In the second experimental design, we did not find significant differences between anodal and sham tDCS.
CONCLUSIONS
Cathodal tDCS over the right DLPFC possibly reduces the pathological overdrive in frontostriatal networks in patients with PD on dopaminergic medication, thus modulating impulsive and risky decision-making.
背景与目的
帕金森病（PD）患者在赌博任务中的表现备受关注，因为病理性赌博常与这些患者的多巴胺替代疗法相关。我们旨在评估经颅直流电刺激（tDCS）作用于右侧背外侧前额叶皮质（DLPFC）对调节PD患者赌博行为的影响。
方法
我们评估了20例PD患者在爱荷华赌博任务中，阴极tDCS作用于右侧DLPFC时的效果，并与假刺激进行比较。然后我们进行了第二个实验设计，评估阳极tDCS作用于右侧DLPFC的效果。
结果
我们观察到，与假刺激相比，阴极tDCS作用于右侧DLPFC时爱荷华赌博任务得分增加。在第二个实验设计中，我们未发现阳极tDCS与假tDCS之间存在显著差异。
结论
阴极tDCS作用于右侧DLPFC可能会降低接受多巴胺能药物治疗的PD患者额纹状体网络中的病理性过度冲动，从而调节冲动和冒险决策。
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