Tian Hui, Shafi Jamil, Ji Mingshan, Bi Yuhui, Yu Zhiguo
College of Plant Protection, Shenyang Agricultural University , Shenyang 110866, People's Republic of China.
Engineering & Technological Research Center of Biopesticide for Liaoning Province , Shenyang 110866, People's Republic of China.
J Nat Prod. 2017 Apr 28;80(4):1015-1019. doi: 10.1021/acs.jnatprod.6b01016. Epub 2017 Mar 15.
One new indole derivative, chloroindole (1), one new diketone, streptoone A (2), two new ketonic acids, streptoones B (3) and C (4), and one known macrolide antibiotic, X-14952B (5), were isolated from Streptomyces sp. SN0280. Extensive NMR, HRESIMS, and IR analysis was used to elucidate their structures. Streptoone A (2) displayed antibacterial activity (MIC value of 7.81 μg/mL) against Clavibater michiganensis, comparable with the positive control streptomycin (MIC value of 7.81 μg/mL). Streptoone B (3) showed antifungal activity (MIC value of 15.63 μg/mL) against Phytophthora capsici (positive control carbendazol MIC value of 7.81 μg/mL). These molecules provide new templates for the potential treatment and management of these phytopathogens.
从链霉菌属SN0280中分离出一种新的吲哚衍生物氯吲哚（1）、一种新的二酮类化合物链霉酮A（2）、两种新的酮酸链霉酮B（3）和链霉酮C（4），以及一种已知的大环内酯类抗生素X-14952B（5）。通过广泛的核磁共振（NMR）、高分辨电喷雾电离质谱（HRESIMS）和红外光谱（IR）分析来阐明它们的结构。链霉酮A（2）对密歇根棒形杆菌显示出抗菌活性（最低抑菌浓度值为7.81μg/mL），与阳性对照链霉素（最低抑菌浓度值为7.81μg/mL）相当。链霉酮B（3）对辣椒疫霉显示出抗真菌活性（最低抑菌浓度值为15.63μg/mL）（阳性对照多菌灵最低抑菌浓度值为7.81μg/mL）。这些分子为这些植物病原体的潜在治疗和管理提供了新的模板。
