Silva Danilo R, Werneck André O, Collings Paul J, Fernandes Rômulo A, Barbosa Décio S, Ronque Enio R V, Sardinha Luís B, Cyrino Edilson S
Study and Research Group in Metabolism, Nutrition and Exercise-GEPEMENE, State University of Londrina-UEL, Londrina, Brazil.
Bradford Institute for Health Research, Bradford NHS Foundation Trust, Bradford, United Kingdom.
Am J Hum Biol. 2017 Sep 10;29(5). doi: 10.1002/ajhb.22995. Epub 2017 Mar 11.
Cardiovascular disease risk markers have become more prevalent in childhood. To provide increased understanding of the etiology of this public health issue, we investigated associations between family characteristics with cardiovascular disease risk markers in adolescents from a developing nation.
In this cross-sectional study data for fasting glucose, lipoproteins (LDL-C and HDL-C), triglycerides, and total cholesterol were collected from 991 adolescents aged 10-17 who were recruited from public schools in Londrina city, Southern Brazil. Family history of cardiovascular disease and parental engagement in risk behavior (alcohol consumption and tobacco smoking) were collected using a self-reported parental questionnaire. Socioeconomic status, adolescent physical activity (estimated by Baecke questionnaire), self-reported tobacco and alcohol intake, and somatic maturation (age at peak height velocity) were used as covariates. Logistic regression was used for the main analyses.
Independent of adolescent lifestyle behaviors, associations (OR [95% CI]) were found between: (1) paternal family history of cardiovascular disease with increased likelihood of high adolescent offspring BMI (1.53 [1.01 to 2.32]) and high triglycerides (2.93 [1.04 to 8.27]); (2) maternal family history of cardiovascular disease with heightened odds of high adolescent offspring triglycerides (2.84 [1.02 to 7.91]); (3) maternal cardiovascular disease with higher odds of high fasting glucose (2.16 [1.13 to 4.14]), and (4) maternal smoking with increased odds of high LDL-C (1.78 [1.14 to 2.79]) and high total cholesterol (1.77 [1.01 to 3.10]) in adolescent offspring.
Family history of cardiovascular disease and maternal tobacco smoking are related to increased cardiovascular risk in adolescents, potentially independent of their own lifestyle behaviors.
心血管疾病风险标志物在儿童期变得更为普遍。为了增进对这一公共卫生问题病因的理解，我们调查了一个发展中国家青少年的家庭特征与心血管疾病风险标志物之间的关联。
在这项横断面研究中，从巴西南部隆德里纳市公立学校招募的991名10至17岁青少年中收集了空腹血糖、脂蛋白（低密度脂蛋白胆固醇和高密度脂蛋白胆固醇）、甘油三酯和总胆固醇的数据。使用一份自我报告的家长问卷收集心血管疾病家族史以及父母的风险行为（饮酒和吸烟）情况。社会经济地位、青少年身体活动（通过贝克问卷估算）、自我报告的烟草和酒精摄入量以及身体成熟度（身高增长峰值时的年龄）用作协变量。主要分析采用逻辑回归。
独立于青少年的生活方式行为，发现以下因素之间存在关联（比值比[95%置信区间]）：（1）父亲的心血管疾病家族史与青少年后代高体重指数（BMI）可能性增加（1.53[1.01至2.32]）以及高甘油三酯可能性增加（2.93[1.04至8.27]）相关；（2）母亲的心血管疾病家族史与青少年后代高甘油三酯几率升高（2.84[1.02至7.91]）相关；（3）母亲患心血管疾病与青少年后代高空腹血糖几率升高（2.16[1.13至4.14]）相关，以及（4）母亲吸烟与青少年后代低密度脂蛋白胆固醇升高（1.78[1.14至2.79]）和总胆固醇升高（1.77[1.01至3.10]）几率增加相关。
心血管疾病家族史和母亲吸烟与青少年心血管风险增加有关，这可能独立于他们自身的生活方式行为。
