Brzezinski Piotr, Borowska Katarzyna, Chiriac Anca, Smigielski Janusz
Institute of Biology and Environmental Protection, Pomeranian Academy, ul. Arciszewskiego 22A, Slupsk, 76-200, Poland.
Department of Dermatology, 6th Military Support Unit, Ustka, Poland.
Dermatol Ther. 2017 Jul;30(4). doi: 10.1111/dth.12483. Epub 2017 Mar 14.
Acne is a very common and disfiguring disease that affects mostly adolescents and, to some extent, adults. The objective of our study was to estimate the adverse effects after isotretinoin by treatment of 3,525 patients due to acne vulgaris in a 5-year observation. Retrospective, comparative study was carried out in Poland and Romania from January 2012 to August 2016. Inclusion criteria into this study were moderate, severe, and nodulocystic inflammatory acne vulgaris. Exclusion criteria were mild acne, pregnant, and lactating women. Statistical analysis was carried out using T test and Chi square. All patients were treated with oral isotretinoin. Patient age ranged from 13-35 years. Dry lips was the most commonly reported adverse effect, affecting 100% of users, followed by xerosis (94.97%) and facial erythema (66.21%). Of all adverse effects, psychiatric symptoms accounted for 25.16%; eye lesions accounted for 8.96%. In lab investigations an increase in the level of total cholesterol and serum triglycerides was observed. This study documents the adverse effect profile of isotretinoin in a large number of patients collected over a period of 4 years. Side effects were mild and well tolerated and did not necessitate stopping the treatment. However, it is important to educate patients about this potential consequence.
痤疮是一种非常常见且有损容貌的疾病，主要影响青少年，在一定程度上也影响成年人。我们研究的目的是通过对3525例寻常痤疮患者进行为期5年的观察，评估异维A酸治疗后的不良反应。2012年1月至2016年8月在波兰和罗马尼亚开展了一项回顾性对比研究。本研究的纳入标准为中度、重度和结节囊肿性炎性寻常痤疮。排除标准为轻度痤疮、孕妇和哺乳期妇女。采用t检验和卡方检验进行统计分析。所有患者均接受口服异维A酸治疗。患者年龄在13至35岁之间。最常报告的不良反应是口干，100%的使用者出现，其次是皮肤干燥（94.97%）和面部红斑（66.21%）。在所有不良反应中，精神症状占25.16%；眼部病变占8.96%。实验室检查发现总胆固醇和血清甘油三酯水平升高。本研究记录了4年期间大量患者使用异维A酸后的不良反应情况。副作用轻微且耐受性良好，无需停止治疗。然而，告知患者这种潜在后果很重要。
