Kucukgoncu S, Zhou E, Lucas K B, Tek C
Department of Psychiatry, School of Medicine, Yale University, New Haven, USA.
Obes Rev. 2017 May;18(5):594-601. doi: 10.1111/obr.12528. Epub 2017 Mar 13.
Obesity is associated with significant morbidity and mortality rates. Even modest weight loss may be associated with health benefits. Alpha-lipoic acid (ALA) is a naturally occurring antioxidant. Studies have suggested anti-obesity properties of ALA; however, results are inconsistent. The purpose of this study is to conduct a meta-analysis of the effect of ALA on weight and body mass index (BMI).
A comprehensive, systematic literature search identified 10 articles on randomized, double-blind, placebo-controlled studies involving ALA. We conducted a meta-analysis of mean weight and BMI change differences between ALA and placebo treatment groups.
Alpha-lipoic acid treatment coincided with a statistically significant 1.27 kg (confidence interval = 0.25 to 2.29) greater mean weight loss compared with the placebo group. A significant overall mean BMI difference of -0.43 kg/ m (confidence interval = -0.82 to -0.03) was found between the ALA and placebo groups. Meta-regression analysis showed no significance in ALA dose on BMI and weight changes. Study duration significantly affected BMI change, but not weight change.
Alpha-lipoic acid treatment showed small, yet significant short-term weight loss compared with placebo. Further research is needed to examine the effect of different doses and the long-term benefits of ALA on weight management.
肥胖与显著的发病率和死亡率相关。即使是适度的体重减轻也可能对健康有益。α-硫辛酸（ALA）是一种天然存在的抗氧化剂。研究表明ALA具有抗肥胖特性；然而，结果并不一致。本研究的目的是对ALA对体重和体重指数（BMI）的影响进行荟萃分析。
通过全面、系统的文献检索，确定了10篇关于ALA的随机、双盲、安慰剂对照研究的文章。我们对ALA治疗组和安慰剂治疗组之间的平均体重和BMI变化差异进行了荟萃分析。
与安慰剂组相比，α-硫辛酸治疗导致平均体重减轻1.27千克，差异具有统计学意义（置信区间为0.25至2.29）。ALA组和安慰剂组之间的总体平均BMI差异显著，为-0.43千克/米²（置信区间为-0.82至-0.03）。荟萃回归分析表明，ALA剂量对BMI和体重变化无显著影响。研究持续时间显著影响BMI变化，但不影响体重变化。
与安慰剂相比，α-硫辛酸治疗显示出少量但显著的短期体重减轻。需要进一步研究以检验不同剂量的效果以及ALA对体重管理的长期益处。
