Brochot Amandine, Guilbot Angèle, Haddioui Laïla, Roques Christine
PiLeJe, Paris Cedex 15, France.
Fonderephar, Toulouse Cedex 09, France.
Microbiologyopen. 2017 Aug;6(4). doi: 10.1002/mbo3.459. Epub 2017 Mar 14.
New agents that are effective against common pathogens are needed particularly for those resistant to conventional antimicrobial agents. Essential oils (EOs) are known for their antimicrobial activity. Using the broth microdilution method, we showed that (1) two unique blends of Cinnamomum zeylanicum, Daucus carota, Eucalyptus globulus and Rosmarinus officinalis EOs (AB1 and AB2; cinnamon EOs from two different suppliers) were active against the fourteen Gram-positive and -negative bacteria strains tested, including some antibiotic-resistant strains. Minimal inhibitory concentrations (MICs) ranged from 0.01% to 3% v/v with minimal bactericidal concentrations from <0.01% to 6.00% v/v; (2) a blend of Cinnamomum zeylanicum, Daucus carota, Syzygium aromaticum, Origanum vulgare EOs was antifungal to the six Candida strains tested, with MICs ranging from 0.01% to 0.05% v/v with minimal fungicidal concentrations from 0.02% to 0.05% v/v. Blend AB1 was also effective against H1N1 and HSV1 viruses. With this dual activity, against H1N1 and against S. aureus and S. pneumoniae notably, AB1 may be interesting to treat influenza and postinfluenza bacterial pneumonia infections. These blends could be very useful in clinical practice to combat common infections including those caused by microorganisms resistant to antimicrobial drugs.
尤其对于那些对传统抗菌药物耐药的病原体，需要有新型有效药物。精油（EOs）以其抗菌活性而闻名。通过肉汤微量稀释法，我们发现：（1）两种独特的由锡兰肉桂、胡萝卜、蓝桉和迷迭香精油组成的混合物（AB1和AB2；来自两个不同供应商的肉桂精油）对所测试的14种革兰氏阳性和阴性细菌菌株具有活性，包括一些抗生素耐药菌株。最低抑菌浓度（MICs）范围为0.01%至3%（v/v），最低杀菌浓度为<0.01%至6.00%（v/v）；（2）一种由锡兰肉桂、胡萝卜、丁香、牛至精油组成的混合物对所测试的6种念珠菌菌株具有抗真菌作用，MICs范围为0.01%至0.05%（v/v），最低杀真菌浓度为0.02%至0.05%（v/v）。混合物AB1对H1N1和HSV1病毒也有效。鉴于其对H1N1以及特别是对金黄色葡萄球菌和肺炎链球菌的双重活性，AB1在治疗流感和流感后细菌性肺炎感染方面可能具有吸引力。这些混合物在临床实践中对于对抗常见感染（包括由对抗菌药物耐药的微生物引起的感染）可能非常有用。
