神经元通过摄取谷氨酸来维持存活。
Neurons eat glutamate to stay alive.
作者信息
Fendt Sarah-Maria, Verstreken Patrik
机构信息
VIB Center for Cancer Biology, Katholieke Universiteit Leuven, 3000 Leuven, Belgium.
Department of Oncology, Katholieke Universiteit Leuven, 3000 Leuven, Belgium.
出版信息
J Cell Biol. 2017 Apr 3;216(4):863-865. doi: 10.1083/jcb.201702003. Epub 2017 Mar 15.
Neurons are thought to primarily rely on glucose to fuel mitochondrial metabolism. In this issue, Divakaruni et al. (2017. https://doi.org/10.1083/jcb.201612067) show that neurons are also happy to use glutamate. When neurons use this neurotransmitter, its concentration drops, thus protecting against glutamate-induced excitotoxic stress.
神经元被认为主要依赖葡萄糖为线粒体代谢提供能量。在本期杂志中，迪瓦卡鲁尼等人（2017年。https://doi.org/10.1083/jcb.201612067）表明，神经元也乐于利用谷氨酸。当神经元使用这种神经递质时，其浓度会下降，从而防止谷氨酸诱导的兴奋性毒性应激。
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