重新评估长链非编码RNA-多梳蛋白功能的基础。
Re-evaluating the foundations of lncRNA-Polycomb function.
作者信息
Blanco Mario R, Guttman Mitchell
机构信息
Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
出版信息
EMBO J. 2017 Apr 13;36(8):964-966. doi: 10.15252/embj.201796796. Epub 2017 Mar 15.
Abstract
Many lncRNAs are thought to interact with the polycomb repressive complex 2 (PRC2) in order to regulate gene expression. A central example of this lncRNA–PRC2 paradigm in gene regulation is . In this issue of a study (Portoso 2017) reports that while binds PRC2 with high affinity, the complex itself is dispensable for ‐mediated transcriptional silencing. This study raises important questions about the role of PRC2 interactions for lncRNA‐mediated functions and argues for a re‐evaluation of this lncRNA–PRC2 functional paradigm.
摘要
许多长链非编码RNA（lncRNA）被认为与多梳抑制复合物2（PRC2）相互作用以调节基因表达。这种lncRNA-PRC2基因调控模式的一个核心例子是 。在本期 中，一项研究（Portoso 2017）报告称，虽然 与PRC2具有高亲和力结合，但该复合物本身对于 -介导的转录沉默是可有可无的。这项研究提出了关于PRC2相互作用在lncRNA介导的功能中的作用的重要问题，并主张重新评估这种lncRNA-PRC2功能模式。
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