饮食限制会增加寿命的变异性。
Dietary restriction increases variability in longevity.
作者信息
Senior A M, Nakagawa S, Raubenheimer D, Simpson S J, Noble D W A
机构信息
Charles Perkins Centre, The University of Sydney, New South Wales 2006, Australia
School of Mathematics and Statistics, The University of Sydney, New South Wales 2006, Australia.
出版信息
Biol Lett. 2017 Mar;13(3). doi: 10.1098/rsbl.2017.0057.
Nutritional environments, particularly those experienced during early life, are hypothesized to affect longevity. A recent cross-taxa meta-analysis found that, depending upon circumstance, average longevity may be increased or decreased by early-life dietary restriction. Unstudied are the effects of diet during development on among-individual variance in longevity. Here, we address this issue using emerging methods for meta-analysis of variance. We found that, in general, standard deviation (s.d.) in longevity is around 8% higher under early-life dietary restriction than a standard diet. The effects became especially profound when dietary insults were experienced prenatally (s.d. increased by 29%) and/or extended into adulthood (s.d. increased by 36.6%). Early-life dietary restriction may generate variance in longevity as a result of increased variance in resource acquisition or allocation, but the mechanisms underlying these largely overlooked patterns clearly warrant elucidation.
营养环境，尤其是生命早期所经历的营养环境，被认为会影响寿命。最近一项跨物种的荟萃分析发现，根据具体情况，生命早期的饮食限制可能会增加或降低平均寿命。发育期间的饮食对个体间寿命差异的影响尚未得到研究。在这里，我们使用新出现的方差荟萃分析方法来解决这个问题。我们发现，一般来说，与标准饮食相比，生命早期饮食限制下寿命的标准差（s.d.）高出约8%。当在产前经历饮食损伤（标准差增加29%）和/或持续到成年期（标准差增加36.6%）时，这种影响变得尤为显著。生命早期的饮食限制可能由于资源获取或分配的差异增加而导致寿命差异，但这些基本被忽视的模式背后的机制显然值得阐明。
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