Zafiropoulos Gregory-George, Deli Giorgio, Hoffmann Oliver, John Gordon
Department of Oral Hygiene, Claudiana University of Applied Health Sciences, Bolzano, Italy.
Division of Periodontology, School of Dentistry, Catholic University, Rome, Italy.
J Indian Soc Periodontol. 2016 Jul-Aug;20(4):441-445. doi: 10.4103/0972-124X.181245.
The aim of this study was to determine the treatment outcome of the use of a porcine monolayer collagen matrix (mCM) to increase soft-tissue volume as a part of implant site development.
Implants were placed in single sites in 27 patients. In the test group, mCM was used for soft-tissue augmentation. No graft was placed in the control group. Soft-tissue thickness (STTh) was measured at the time of surgery (T0) and 6 months postoperatively (T1) at two sites (STTh 1, 1 mm below the gingival margin; STTh 2, 3 mm below the mucogingival margin).
Significant increases ( < 0.001) in STTh (STTh 1 = 1.06 mm, 117%; STTh 2 = 0.89 mm, 81%) were observed in the test group. Biopsy results showed angiogenesis and mature connective tissue covered by keratinized epithelium.
Within the limitations of this study, it could be concluded that mCM leads to a significant increase of peri-implant soft-tissue thickness, with good histological integration and replacement by soft tissue and may serve as an alternative to connective tissue grafting.
本研究的目的是确定使用猪单层胶原基质（mCM）增加软组织体积作为种植位点开发一部分的治疗效果。
在27例患者的单个位点植入种植体。试验组使用mCM进行软组织增量。对照组未植入移植物。在手术时（T0）和术后6个月（T1）在两个位点测量软组织厚度（STTh）（STTh 1，龈缘下方1mm；STTh 2，膜龈联合下方3mm）。
试验组STTh显著增加（<0.001）（STTh 1 = 1.06mm，增加117%；STTh 2 = 0.89mm，增加81%）。活检结果显示有血管生成以及角化上皮覆盖的成熟结缔组织。
在本研究的局限性范围内，可以得出结论，mCM可导致种植体周围软组织厚度显著增加，具有良好的组织学整合以及软组织替代，并且可作为结缔组织移植的一种替代方法。
