Research Unit in Periodontology and Periodontal Medicine, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy.
Private Practice, Florence, Italy.
J Clin Periodontol. 2017 Jul;44(7):769-776. doi: 10.1111/jcpe.12750. Epub 2017 Jun 29.
Peri-implant soft tissue may be critical to prevent inflammation and promote gingival margin stability. The purpose of this randomized clinical trial (RCT) is to compare xenogeneic collagen matrix (XCM) versus connective tissue graft (CTG) to increase buccal soft tissue thickness at implant site.
Soft tissue augmentation with XCM (test) or CTG (control) was performed at 60 implants in 60 patients at the time of implant uncovering. Measurements were performed by a blinded examiner at baseline, 3 and 6 months. Outcome measures included buccal soft tissue thickness (GT), apico-coronal keratinized tissue (KT), chair time and post-operative discomfort. Visual Analogue Scale (VAS) was used to evaluate patient satisfaction.
After 6 months, the final GT increase was 0.9 ± 0.2 in the XCM group and 1.2 ± 0.3 mm in the CTG group, with a significant difference favouring the control group (0.3 mm; p = .0001). Both procedures resulted in similar final KT amount with no significant difference between treatments. XCM was associated with significant less chair-time (p < .0001), less post-operative pain (p < .0001), painkillers intake (p < .0001) and higher final satisfaction than CTG (p = .0195).
CTG was more effective than XCM to increase buccal peri-implant soft tissue thickness.
种植体周围的软组织对于预防炎症和促进牙龈边缘稳定性至关重要。本随机临床试验（RCT）旨在比较异种胶原基质（XCM）与结缔组织移植物（CTG）在增加种植体部位颊侧软组织厚度方面的效果。
在 60 名患者的 60 个种植体上，于种植体暴露时进行 XCM（试验）或 CTG（对照）软组织增强。由盲法检查者在基线、3 个月和 6 个月时进行测量。观察指标包括颊侧软组织厚度（GT）、根尖-冠向角化组织（KT）、椅旁时间和术后不适。使用视觉模拟量表（VAS）评估患者满意度。
6 个月后，XCM 组 GT 的最终增加量为 0.9±0.2mm，CTG 组为 1.2±0.3mm，对照组有显著优势（0.3mm；p=0.0001）。两种方法最终获得的 KT 量相似，治疗之间无显著差异。XCM 组椅旁时间显著缩短（p<0.0001），术后疼痛（p<0.0001）、止痛药使用（p<0.0001）和最终满意度（p=0.0195）均高于 CTG 组。
与 XCM 相比，CTG 更能有效增加种植体周围颊侧软组织厚度。
