Fathiazar Alireza, Shariatmadar Ahmadi Roya, Sayar Ferena
Dept. of Periodontics, Faculty of Dentistry, Ardabil University of Medical Sciences, Ardabil, Iran.
Dept. of Periodontics, Faculty of Dentistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
J Dent (Shiraz). 2022 Sep;23(2 Suppl):402-409. doi: 10.30476/DENTJODS.2021.90830.1535.
Subepithelial connective tissue graft (SCTG) is the gold stand-ard treatment for root coverage procedure; however, this technique has limitations such as the need for a donor site and the difficulty of the harvesting procedure. The potential bene-fits of Mucoderm®, a collagen matrix derived from porcine dermis, as an alternative treat-ment for root coverage can be investigated.
This study aimed to evaluate the efficacy of Mucoderm® for root coverage and compare its results with SCTG.
This double-blind split-mouth randomized clinical trial was con-ducted on seven patients with 12 bilateral gingival recessions (24 recession sites). Coronally advanced flap + Mucoderm® was applied on one side and coronally advanced flap + con-nective tissue graft (CTG) was applied on the contralateral side. We measured the periodon-tal pocket depth (PPD), clinical attachment level (CAL), recession depth (RD), keratinized tissue width (KTW) and gingival thickness (GT) with a surgical stent at baseline (preopera-tively) and at 1, 3 and 6 months postoperatively. The Wilcoxon and Friedman tests were used to analyse the data.
The mean percentage of root coverage was 26% in the Mucoderm® group and 60% in the SCTG group at 6 months, compared with baseline. The mean percentage of root coverage was significantly different between the two groups ( Value< 0.05). The results indicated that Mucoderm® did not increase the KTW, while CTG significantly increased the KTW ( Value< 0.05 at 1, 3 and 6 months).
The results of this study showed that Mucoderm® might not be an appropriate alternative for the CTG in root coverage procedures.
上皮下结缔组织移植术（SCTG）是牙根覆盖术的金标准治疗方法；然而，该技术存在局限性，如需要供体部位以及采集过程困难。可以研究源自猪真皮的胶原基质Mucoderm®作为牙根覆盖替代治疗方法的潜在益处。
本研究旨在评估Mucoderm®用于牙根覆盖的疗效，并将其结果与SCTG进行比较。
本双盲、双侧分口随机临床试验对7例患者的12处双侧牙龈退缩（24个退缩部位）进行。一侧应用冠向复位瓣 + Mucoderm®，对侧应用冠向复位瓣 + 结缔组织移植术（CTG）。我们在基线（术前）以及术后1、3和6个月使用手术定位器测量牙周袋深度（PPD）、临床附着水平（CAL）、退缩深度（RD）、角化组织宽度（KTW）和牙龈厚度（GT）。采用Wilcoxon检验和Friedman检验分析数据。
与基线相比，6个月时Mucoderm®组牙根覆盖的平均百分比为26%，SCTG组为60%。两组之间牙根覆盖的平均百分比有显著差异（P值<0.05）。结果表明，Mucoderm®未增加KTW，而CTG显著增加了KTW（在1、3和6个月时P值<0.05）。
本研究结果表明，在牙根覆盖手术中，Mucoderm®可能不是CTG的合适替代物。
