Hussain Rehan M, Abbey Ashkan M, Shah Ankoor R, Drenser Kimberly A, Trese Michael T, Capone Antonio
Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Department of Ophthalmology, Associated Retinal Consultants, Oakland University William Beaumont School of Medicine, Royal Oak, Michigan, USA.
J Ophthalmic Vis Res. 2017 Jan-Mar;12(1):3-10. doi: 10.4103/2008-322X.200163.
To report the chorioretinal coloboma, and its association with increased risk of retinal detachment (RD) and choroidal neovascularization (CNV).
This retrospective case series included eyes with chorioretinal coloboma diagnosed between 1995 and 2014 with a focus on RD and CNV as related complications. Cases of CNV were managed with laser photocoagulation or intravitreal injection of bevacizumab. For eyes with CNV, therapeutic success was defined as resolution of the subretinal hemorrhage on fundus examination and resolution of the subretinal and intraretinal fluid on optical coherence tomography (OCT). For eyes with RD, anatomic success following surgical intervention was defined as attachment of the retina at the last follow-up visit.
Fifty-one eyes of 31 patients with chorioretinal coloboma were identified for review. Bilateral chorioretinal coloboma was present in 64.5% of subjects. RD developed in 15 eyes (29.4%). Among 15 eyes with RD, 4 eyes (27%) had retinal breaks identified within the coloboma, 5 eyes (33%) had retinal breaks outside the coloboma, 2 eyes (13%) showed retinal breaks both inside and outside the coloboma, and in 4 eyes (27%) the causative retinal break was not localized. The overall rate of anatomic success after RD repair was 85.7%. CNV developed in 7 eyes (13.7%) and was located along the margin of the coloboma in all cases. CNV was bilateral in 2 of the 5 affected individuals (40%).
RD and CNV were present in a high percentage of eyes with chorioretinal coloboma in these series. The frequent finding of retinal breaks outside the coloboma bed suggests that vitreoretinal interface abnormalities may play a role in development of RD in these eyes.
报告脉络膜视网膜缺损及其与视网膜脱离（RD）和脉络膜新生血管（CNV）风险增加的相关性。
本回顾性病例系列纳入了1995年至2014年间诊断为脉络膜视网膜缺损的眼睛，重点关注作为相关并发症的RD和CNV。CNV病例采用激光光凝或玻璃体腔内注射贝伐单抗治疗。对于患有CNV的眼睛，治疗成功定义为眼底检查时视网膜下出血消退以及光学相干断层扫描（OCT）显示视网膜下和视网膜内液体积聚消退。对于患有RD的眼睛，手术干预后的解剖学成功定义为在最后一次随访时视网膜复位。
确定了31例脉络膜视网膜缺损患者的51只眼睛进行回顾。64.5%的受试者存在双侧脉络膜视网膜缺损。15只眼睛（29.4%）发生了RD。在15只发生RD的眼睛中，4只眼睛（27%）在缺损区内发现视网膜裂孔，5只眼睛（33%）在缺损区外发现视网膜裂孔，2只眼睛（13%）在缺损区内和外均显示视网膜裂孔，4只眼睛（27%）未定位到引起RD的视网膜裂孔。RD修复后的总体解剖学成功率为85.7%。7只眼睛（13.7%）发生了CNV，所有病例均位于缺损边缘。5例受影响个体中有2例（40%）的CNV为双侧性。
在这些系列中，高比例的脉络膜视网膜缺损眼睛存在RD和CNV。在缺损区床外频繁发现视网膜裂孔表明玻璃体视网膜界面异常可能在这些眼睛的RD发生中起作用。
