Faghihi Gita, Taheri Azam, Shahmoradi Zabihollah, Nilforoushzadeh Mohammad Ali
Skin Disease and Leishmaniasis Research Center, Department of Dermatology, Isfahan University of Medical Sciences, Isfahan, Iran.
Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Adv Biomed Res. 2017 Feb 22;6:9. doi: 10.4103/2277-9175.200784. eCollection 2017.
Melasma, a common acquired disorder of hyperpigmentation, especially in women, is often resistant to therapy. This study was aimed to evaluate the efficacy and safety of azelaic acid, resorcinol and phytic acid solution in chemical peeling of melasma in comparison to 50% glycolic acid.
This clinical trial was performed, on 42 female patients with bilateral melasma. Severity of melasma was assessed by melasma area and severity index (MASI). Combination of (20% azelaic acid + 10% resorcinol + 6% phytic acid) was used as a new peeling agent on the right side of the face and 50% glycolic acid on the left side every 2 weeks for 6 times. Follow-up was carried out for 3 months after the last session. Any decrease in MASI score and unwanted complications following peeling were evaluated and compared during the trial.
Patients showed marked improvement as calculated with MASI score before and after treatment in both sides of the face. The efficacy of combination formula (azelaic acid, resorcinol and phytic acid) was similar to glycolic acid, but with fewer complications. There was no statistically difference in improvement between two groups ( > 0.05). However, the patient's discomfort following procedures was significantly lower with azelaic acid, resorcinol and phytic compared with the glycolic acid peels ( < 0.05) and there was the same duration in the beginning of the therapeutic response in both groups.
Results showed that triple-combination was found to be an effective and safe peeling agent in the treatment of melasma and it was as effective as 50% glycolic acid peel.
黄褐斑是一种常见的获得性色素沉着紊乱疾病，尤其在女性中较为常见，且往往对治疗具有抵抗性。本研究旨在评估壬二酸、间苯二酚和植酸溶液与50%乙醇酸相比，在黄褐斑化学剥脱治疗中的疗效和安全性。
对42例双侧黄褐斑女性患者进行了这项临床试验。通过黄褐斑面积和严重程度指数（MASI）评估黄褐斑的严重程度。将（20%壬二酸+10%间苯二酚+6%植酸）组合用作新的剥脱剂，每2周在面部右侧使用一次，左侧使用50%乙醇酸，共进行6次。在最后一次治疗后进行3个月的随访。在试验期间评估并比较剥脱后MASI评分的任何降低以及不良并发症。
根据面部两侧治疗前后的MASI评分计算，患者显示出明显改善。组合配方（壬二酸、间苯二酚和植酸）的疗效与乙醇酸相似，但并发症较少。两组之间的改善情况无统计学差异（>0.05）。然而，与乙醇酸剥脱相比，使用壬二酸、间苯二酚和植酸后患者术后不适明显更低（<0.05）且两组治疗反应开始的持续时间相同。
结果表明，三联组合在治疗黄褐斑方面是一种有效且安全的剥脱剂，其效果与50%乙醇酸剥脱相同。
