Akhgari Amir, Oksman-Caldentey Kirsi-Marja, Rischer Heiko
Department of Biochemistry, University of Turku, Vatselankatu 2, 20014, Turku, Finland.
VTT Technical Research Centre of Finland Ltd., Tietotie 2, P.O. Box 1000, 02044, Espoo, Finland.
Biotechnol Lett. 2017 Jun;39(6):829-840. doi: 10.1007/s10529-017-2320-7. Epub 2017 Mar 15.
Rhazya stricta Decne. (Apocynaceae) is an important medicinal plant that is widely distributed in the Middle East and Indian sub-continent. It produces a large number of terpenoid indole alkaloids (TIAs) some of which possess important pharmacological properties. However, the yields of these compounds are very low. Establishment of a reliable, reproducible and efficient transformation method and induction of hairy roots system is a vital prerequisite for application of biotechnology in order to improve secondary metabolite yields. In the present review, recent biotechnological attempts and advances in TIAs production through transformed hairy root cultures in R. stricta are reviewed to draw the attention to its metabolic engineering potential.
沙漠玫瑰（夹竹桃科）是一种重要的药用植物，广泛分布于中东和印度次大陆。它能产生大量的萜类吲哚生物碱（TIAs），其中一些具有重要的药理特性。然而，这些化合物的产量非常低。建立可靠、可重复且高效的转化方法以及诱导毛状根系统是应用生物技术提高次生代谢产物产量的关键前提。在本综述中，对通过转化沙漠玫瑰毛状根培养生产TIAs的最新生物技术尝试和进展进行了综述，以引起人们对其代谢工程潜力的关注。
