Drexel University, School of Biomedical Engineering, Philadelphia, Pennsylvania, United States.
Drexel University, College of Medicine, Department of Surgery, Philadelphia, Pennsylvania, United States.
J Biomed Opt. 2017 Feb 1;22(2):25003. doi: 10.1117/1.JBO.22.2.025003.
Pressure injuries (PIs) originate beneath the surface of the skin at the interface between bone and soft tissue. We used diffuse correlation spectroscopy (DCS) and diffuse near-infrared spectroscopy (DNIRS) to predict the development of PIs by measuring dermal and subcutaneous red cell motion and optical absorption and scattering properties in 11 spinal cord injury subjects with only nonbleachable redness in the sacrococcygeal area in a rehabilitation hospital and 20 healthy volunteers. A custom optical probe was developed to obtain continuous DCS and DNIRS data from sacrococcygeal tissue while the subjects were placed in supine and lateral positions to apply pressure from body weight and to release pressure, respectively. Rehabilitation patients were measured up to four times over a two-week period. Three rehabilitation patients developed open PIs (POs) within four weeks and eight patients did not (PNOs). Temporal correlation functions in the area of redness were significantly different ( p < 0.01 ) during both baseline and applied pressure stages for POs and PNOs. The results show that our optical method may be used for the early prediction of ulcer progression.
压力性损伤（PI）起源于皮肤表面以下，在骨骼和软组织之间的界面处。我们使用漫反射相关光谱（DCS）和漫反射近红外光谱（DNIRS）通过测量 11 名脊髓损伤患者和 20 名健康志愿者骶尾部区域仅有不可漂白的红斑处的皮肤和皮下红细胞运动以及光吸收和散射特性，来预测 PI 的发展。在康复医院，一个定制的光学探头被开发出来，以便在受试者处于仰卧位和侧卧位时，从骶尾部组织中获得连续的 DCS 和 DNIRS 数据，以分别施加和释放体重压力。康复患者在两周内最多测量四次。三名康复患者在四周内发展为开放性压力性损伤（PO），八名患者没有（PNO）。PO 和 PNO 在基线和施加压力阶段的红斑区域的时间相关函数差异均具有统计学意义（p<0.01）。结果表明，我们的光学方法可用于溃疡进展的早期预测。
