用于高效富集肽段并同时排除蛋白质的核壳结构磁性共价有机框架的室温合成
Room-temperature synthesis of core-shell structured magnetic covalent organic frameworks for efficient enrichment of peptides and simultaneous exclusion of proteins.
作者信息
Lin Guo, Gao Chaohong, Zheng Qiong, Lei Zhixian, Geng Huijuan, Lin Zian, Yang Huanghao, Cai Zongwei
机构信息
Ministry of Education Key Laboratory of Analysis and Detection for Food Safety, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China.
Partner State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, 224 Waterloo Road, Kowloon Tong, Hong Kong SAR, P. R. China.
出版信息
Chem Commun (Camb). 2017 Mar 28;53(26):3649-3652. doi: 10.1039/c7cc00482f.
Core-shell structured magnetic covalent organic frameworks (FeO@COFs) were synthesized via a facile approach at room temperature. Combining the advantages of high porosity, magnetic responsiveness, chemical stability and selectivity, FeO@COFs can serve as an ideal absorbent for the highly efficient enrichment of peptides and the simultaneous exclusion of proteins from complex biological samples.
通过一种简便的方法在室温下合成了核壳结构的磁性共价有机框架（FeO@COFs）。FeO@COFs结合了高孔隙率、磁响应性、化学稳定性和选择性等优点，可作为一种理想的吸附剂，用于从复杂生物样品中高效富集肽并同时排除蛋白质。
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