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在果蝇中寻找反式调控基因的基因剂量滴定分析。

Gene-dose titration analysis in the search of trans-regulatory genes in Drosophila.

作者信息

Botas J, Moscoso del Prado J, García-Bellido A

出版信息

EMBO J. 1982;1(3):307-10. doi: 10.1002/j.1460-2075.1982.tb01165.x.

DOI:10.1002/j.1460-2075.1982.tb01165.x
PMID:7188185
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC553040/
Abstract

We have searched for trans-regulatory genes in two genetic systems in Drosophila, the bithorax complex (BX-C) and the achaete-scute complex (AS-C). Previous genetic evidence suggests that the activation of both BX-C and AS-C, depends on trans-regulatory genes (Polycomb, Pc, in the former and hairy, h, in the latter) acting in a negative type of control. Mutants of these regulatory genes in heterozygous condition have dominant derepression phenotypes in flies with extra doses of the corresponding gene complexes. We have searched for new loci, with similar gene-dose relationships. We have isolated only new alleles (six) of Pc in the BX-C experiment. In the AS-C experiment four h alleles, and 13 alleles of a new locus (extramacrochaetae, emc) have been discovered. Whereas the h locus shows specific interactions upon achaete, the new locus, emc, is specific for the scute part of the AS-C. Statistical analysis suggests that these are the only loci in the genome with those dose-dependent properties in the two systems.

摘要

我们在果蝇的两个遗传系统，即双胸复合体（BX-C）和achaete-scute复合体（AS-C）中寻找反式调控基因。先前的遗传学证据表明，BX-C和AS-C的激活均依赖于以负调控类型起作用的反式调控基因（前者中的多梳蛋白，Pc，以及后者中的毛状体，h）。这些调控基因的杂合突变体在具有额外剂量相应基因复合体的果蝇中具有显性去抑制表型。我们寻找了具有相似基因剂量关系的新位点。在BX-C实验中，我们仅分离到Pc的新等位基因（六个）。在AS-C实验中，发现了四个h等位基因以及一个新位点（extra macrochaetae，emc）的13个等位基因。虽然h位点对achaete表现出特异性相互作用，但新位点emc对AS-C的scute部分具有特异性。统计分析表明，在这两个系统中，这些是基因组中仅有的具有那些剂量依赖性特性的位点。