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Fission yeast tmsl protein abrogates normal development in Xenopus laevis embryos.

作者信息

Wagner Peter, Hoever Michael, Appel Katrin, Knöchel Walter, Montenarh Mathias

机构信息

Medizinische Biochemie, Universität des Saarlandes, Gebdude 44, D-66421, Homburg/Saar, Germany.

Abteilung Biochemie, Universität Ulm, Albert Einstein Allee 11, D-89069, Ulm, Germany.

出版信息

Rouxs Arch Dev Biol. 1995 Jan;204(3):198-202. doi: 10.1007/BF00241273.

DOI:10.1007/BF00241273
PMID:28305960
Abstract

Recently we cloned tms1 (a putative dehydrogenase) by complementation of a human tumour-derived mutant p53 induced growth arrest in fission yeast. Microinjection of purified tmsl protein into Xenopus laevis embryos abrogated normal embryo development by causing cleavage retardation or cleavage arrest of injected blastomeres in a concentration dependant manner, whereas injection of specific affinity purified tms1 antiserum showed no significant morphological defects. Microinjection of tms1 protein together with affinity purified tms1 antibody resulted in a significantly reduced number of cleavage arrested embryos.

摘要

相似文献

1
Fission yeast tmsl protein abrogates normal development in Xenopus laevis embryos.
Rouxs Arch Dev Biol. 1995 Jan;204(3):198-202. doi: 10.1007/BF00241273.
2
P53 forms tight complexes with tms1 of fission yeast.P53与裂殖酵母的tms1形成紧密复合物。
Int J Oncol. 1994 Apr;4(4):987-92.
3
Putative dehydrogenase tms1 suppresses growth arrest induced by a p53 tumour mutant in fission yeast.假定的脱氢酶tms1可抑制裂殖酵母中由p53肿瘤突变体诱导的生长停滞。
Eur J Biochem. 1993 Oct 15;217(2):731-6. doi: 10.1111/j.1432-1033.1993.tb18299.x.
4
Phosphorylation mutants of p53 show differential complex formation with putative dehydrogenase Tms1 of fission yeast.p53的磷酸化突变体与裂殖酵母中假定的脱氢酶Tms1形成不同的复合物。
Eur J Biochem. 1997 Sep 1;248(2):441-4. doi: 10.1111/j.1432-1033.1997.t01-1-00441.x.
5
Cytological effects of the microinjection of antibody to ras p21 in early cleavage Xenopus embryos.向非洲爪蟾早期卵裂胚胎显微注射抗ras p21抗体的细胞学效应。
Mol Reprod Dev. 1990 Apr;25(4):317-27. doi: 10.1002/mrd.1080250403.
6
Definition of the p53 binding-site on the tms1 protein.tms1蛋白上p53结合位点的定义。
Int J Oncol. 1995 Jul;7(1):171-5.
7
Precise mapping of the tms1 binding site on p53.p53上tms1结合位点的精确映射。
FEBS Lett. 1995 Dec 18;377(2):155-8. doi: 10.1016/0014-5793(95)01329-6.
8
A new 42-kda protein-binding to the growth suppressor protein-p53.一种新的 42kDa 蛋白与生长抑制蛋白-p53 结合。
Int J Oncol. 1994 Sep;5(3):667-73. doi: 10.3892/ijo.5.3.667.
9
Overexpression of wild-type p53 interferes with normal development in Xenopus laevis embryos.
Oncogene. 1994 Jan;9(1):109-20.
10
Asters play only a dispensable role in the induction of the cleavage furrow in the blastomeres of early Xenopus embryos.星体在非洲爪蟾早期胚胎卵裂球中分裂沟的诱导过程中仅起非必需作用。
Dev Growth Differ. 2004 Aug;46(4):371-81. doi: 10.1111/j.1440-169x.2004.00754.x.

本文引用的文献

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P53 forms tight complexes with tms1 of fission yeast.P53与裂殖酵母的tms1形成紧密复合物。
Int J Oncol. 1994 Apr;4(4):987-92.
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A new 42-kda protein-binding to the growth suppressor protein-p53.一种新的 42kDa 蛋白与生长抑制蛋白-p53 结合。
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Overexpression of wild-type p53 interferes with normal development in Xenopus laevis embryos.
Oncogene. 1994 Jan;9(1):109-20.
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Putative dehydrogenase tms1 suppresses growth arrest induced by a p53 tumour mutant in fission yeast.假定的脱氢酶tms1可抑制裂殖酵母中由p53肿瘤突变体诱导的生长停滞。
Eur J Biochem. 1993 Oct 15;217(2):731-6. doi: 10.1111/j.1432-1033.1993.tb18299.x.
7
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Mutation is required to activate the p53 gene for cooperation with the ras oncogene and transformation.需要突变来激活p53基因，以便与ras癌基因协同作用并实现转化。
J Virol. 1989 Feb;63(2):739-46. doi: 10.1128/JVI.63.2.739-746.1989.
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Simple and complex cell cycles.简单和复杂的细胞周期。
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