Fraser J R, Tait B, Aaskov J G, Cunningham A L
Aust N Z J Med. 1980 Dec;10(6):597-603. doi: 10.1111/j.1445-5994.1980.tb04238.x.
HLA D locus-related (DR) antigens and Gm phenotypes were determined in 30 patients with epidemic polyarthritis following Ross River virus (RRV) infection and contrasted with those in comparison series of 119 (DR) and 1220 (Gm) normal subjects. HLA DR7 (46.7% cf. 21.0%) and the heterozygous Gm phenotype a+x+b+ (33.3% cf. 15.3%) were significantly increased in the patients, with relative risks of 3.3 and 2.8 respectively. The occurrence of Gm a+x+b+ was independent of DR7, and conferred a relative risk of 4.3 in DR7-negative patients. Differences found in clinical features, specific lymphocyte proliferative responses and antibody titres did not reach significant levels. The association with DR7 was inversely related to age in residents of an area of moderate endemic risk, and to levels of natural cell-mediated immunity (natural killer cell activity). These correlations point to possible mechanisms by which genetic traits might influence the occurrence or consequence of RRV infection.
对30例感染罗斯河病毒（RRV）后发生流行性多关节炎的患者进行了人类白细胞抗原D位点相关（DR）抗原和Gm表型检测，并与119名（DR）和1220名（Gm）正常对照者的检测结果进行对比。患者中HLA DR7（46.7% 对比21.0%）和杂合Gm表型a+x+b+（33.3% 对比15.3%）显著增加，相对风险分别为3.3和2.8。Gm a+x+b+的出现与DR7无关，在DR7阴性患者中相对风险为4.3。在临床特征、特异性淋巴细胞增殖反应和抗体滴度方面发现的差异未达到显著水平。在中度地方病风险地区的居民中，与DR7的关联与年龄呈负相关，与自然细胞介导免疫水平（自然杀伤细胞活性）呈负相关。这些相关性指出了遗传特征可能影响RRV感染发生或后果的潜在机制。
