Stuart J M, Huffstutter E H, Townes A S, Kang A H
Arthritis Rheum. 1983 Jul;26(7):832-40. doi: 10.1002/art.1780260703.
Antibodies to human native and denatured types I, II, III, IV, and V collagens were measured using 125I-radioimmunoassay. Mean levels of binding by sera from 30 rheumatoid arthritis patients were significantly higher than those from 20 normal subjects against all of the collagens tested. The relative antibody concentration was higher in synovial fluid than in simultaneously obtained serum. Many patients with gout or various other rheumatic diseases also had detectable anticollagen antibodies. With a few notable exceptions, the majority of the reactivity detected in all patient groups was directed against covalent structural determinants present on all of the denatured collagens, suggesting a secondary reaction to tissue injury.
采用¹²⁵I放射免疫分析法检测了针对人天然和变性I、II、III、IV和V型胶原蛋白的抗体。30例类风湿性关节炎患者血清的平均结合水平显著高于20例正常受试者血清针对所有检测胶原蛋白的结合水平。滑液中的相对抗体浓度高于同时采集的血清。许多痛风或其他各种风湿性疾病患者也可检测到抗胶原蛋白抗体。除少数显著例外，所有患者组中检测到的大部分反应性均针对所有变性胶原蛋白上存在的共价结构决定簇，提示这是对组织损伤的继发反应。
