Osunkoya B O, Ajayi O, Akinyemi A A, Ukaejiofo E O
Postgraduate Institute of Medical Research and Training, College of Medicine, Ibadan, Nigeria.
Afr J Med Med Sci. 1987 Dec;16(4):181-6.
Previously described giant multinucleated cells were observed in phytohaemagglutinin (PHA) cultures of washed leucocytes from blood samples of seventeen (36%) out of forty-seven children with measles or undiagnosed fever in Ibadan. The giant cells were more readily seen in PHA cultures of purified lymphocyte preparations than in total leucocyte suspensions. It was concluded that the giant cells seen in cultures indicate in-vivo infection of some blood lymphocytes of patients with measles and related infections by syncytium-producing virus. The practical application of lymphocyte cultures to the laboratory diagnosis of measles is stressed, and the concept of circulating lymphocytes acting as vehicles for the systemic spread of measles infection is highlighted.
在伊巴丹，对47名患麻疹或未确诊发热儿童的血样进行白细胞洗涤，然后在植物血凝素（PHA）培养物中观察到了之前所描述的巨型多核细胞，其中17名（36%）儿童出现这种情况。在纯化淋巴细胞制剂的PHA培养物中比在全白细胞悬液中更容易看到这些巨型细胞。得出的结论是，培养物中看到的巨型细胞表明麻疹及相关感染患者的一些血液淋巴细胞在体内受到了产生多核细胞的病毒感染。强调了淋巴细胞培养在麻疹实验室诊断中的实际应用，并突出了循环淋巴细胞作为麻疹感染全身传播载体的概念。
