乳腺中的非自主性细胞增殖与癌症
Non-autonomous cell proliferation in the mammary gland and cancer.
作者信息
Weber Robert J, Desai Tejal A, Gartner Zev J
机构信息
Department of Pharmaceutical Chemistry, University of California, San Francisco, 600 16th Street, San Francisco, California 94158, United States; Chemistry and Chemical Biology Graduate Program, University of California, San Francisco, 600 16th Street, Room 522, San Francisco, California 94158, United States; Medical Scientist Training Program, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, California 94143, United States.
UC Berkeley-UCSF Group in Bioengineering, 1700 Fourth Street, Room 216, San Francisco, California 94158, United States; UCSF Bioengineering and Therapeutic Sciences, 1700 Fourth Street, Room 216B, San Francisco, California 94158, United States.
出版信息
Curr Opin Cell Biol. 2017 Apr;45:55-61. doi: 10.1016/j.ceb.2017.02.009. Epub 2017 Mar 15.
Cells decide whether to grow and divide by integrating internal and external signals. Non-autonomous cell growth and proliferation occurs when microenvironmental signals from neighboring cells, both physical and secreted, license this decision. Understanding these processes is vital to developing an accurate framework for cell-cell interactions and cellular decision-making, and is useful for advancing new therapeutic strategies to prevent dysregulated growth. Here, we review some recent examples of non-autonomous cell growth in the mammary gland and tumor cell proliferation.
细胞通过整合内部和外部信号来决定是否生长和分裂。当来自邻近细胞的物理和分泌的微环境信号许可这一决定时，就会发生非自主性细胞生长和增殖。了解这些过程对于建立准确的细胞间相互作用和细胞决策框架至关重要，并且有助于推进预防生长失调的新治疗策略。在这里，我们回顾一些乳腺中非自主性细胞生长和肿瘤细胞增殖的最新例子。
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