Lin Jack, Zhu Ziwen, Xiao Huaping, Wakefield Mark R, Ding Vivi A, Bai Qian, Fang Yujiang
Department of Microbiology, Immunology and Pathology, Des Moines University, Des Moines, IA, U.S.A.
Department of Surgery, University of Missouri School of Medicine, Columbia, MO, U.S.A.
Anticancer Res. 2017 Mar;37(3):963-967. doi: 10.21873/anticanres.11405.
Interleukin-7 (IL-7) is a cytokine that has been known since long in immunology, mainly regarding its effects on T-cells and B-cells. IL-7 has been demonstrated to be necessary for both B-cell and T-cell proliferation and lack of IL-7 causes immature immune cell arrest. Interestingly, in recent years, certain studies have strongly suggested that the role of IL-7 is far beyond the field of immunology, it might have direct or indirect effect on cancer. This review aims to summarize the role of IL-7 in immunity and its role in the pathogenesis of neoplasia.
白细胞介素-7（IL-7）是一种在免疫学领域早已为人所知的细胞因子，主要涉及其对T细胞和B细胞的作用。IL-7已被证明对B细胞和T细胞的增殖都是必需的，缺乏IL-7会导致未成熟免疫细胞停滞。有趣的是，近年来，某些研究强烈表明，IL-7的作用远远超出了免疫学领域，它可能对癌症有直接或间接影响。这篇综述旨在总结IL-7在免疫中的作用及其在肿瘤发生机制中的作用。
