Vasudevan A, Bogdan A R, Koolman H F, Wang Y, Djuric S W
Discovery Chemistry and Technology, North Chicago, IL, United States.
Prog Med Chem. 2017;56:1-35. doi: 10.1016/bs.pmch.2016.11.001. Epub 2017 Feb 10.
There is a pressing need to improve overall productivity in the pharmaceutical industry. Judicious investments in chemistry technologies can have a significant impact on cycle times, cost of goods and probability of technical success. This perspective describes some of these technologies developed and implemented at AbbVie, and their applications to the synthesis of novel scaffolds and to parallel synthesis.
制药行业迫切需要提高整体生产率。对化学技术进行明智投资能够对周期时间、商品成本以及技术成功概率产生重大影响。本文阐述了艾伯维公司开发并应用的部分此类技术，以及它们在新型骨架合成和平行合成中的应用。
