Kezios Katrina, Gu Yiwei, Liu Xinhua, Cirillo Piera, Tarrant Darcy, Petreas Myrto, Park Jun-Soo, Cohn Barbara, Factor-Litvak Pam
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA.
Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY 10032, USA.
Reprod Toxicol. 2017 Aug;71:166-175. doi: 10.1016/j.reprotox.2017.02.015. Epub 2017 Mar 15.
In a sample of 442 births from the Child Health and Development Studies cohort, we examined associations between maternal prenatal exposure to hydroxylated polychlorinated biphenyl metabolites (OH-PCBs) and pregnancy outcomes, and whether associations were mediated by maternal thyroid hormone levels and/or modified by maternal smoking. Compared to nonsmokers, smokers had twice the mean concentration of 4-OH-CB107 (p<0.001) and lower levels of its parent compound, PCB118 (p=0.001). Among mothers who smoked, the birth weight of newborns with maternal concentrations of 4-OH-CB107 in the upper quartile was 316g lighter (95% confidence interval (CI) 566, 65) compared to those with maternal concentrations in the lowest quartile, after control for PCB118 and other potential confounders. This association was not observed for non-smoking mothers and was not mediated by maternal thyroid hormone levels. Maternal prenatal 4-OH-CB107 levels appear to be influenced by maternal smoking and contribute to lower birth weight among smokers.
在儿童健康与发展研究队列的442例出生样本中，我们研究了母亲孕期接触羟基化多氯联苯代谢物（OH-PCBs）与妊娠结局之间的关联，以及这些关联是否由母亲甲状腺激素水平介导和/或受母亲吸烟的影响。与不吸烟者相比，吸烟者的4-羟基联苯107（4-OH-CB107）平均浓度高出两倍（p<0.001），而其母体化合物多氯联苯118（PCB118）的水平较低（p=0.001）。在吸烟母亲中，在控制了PCB118和其他潜在混杂因素后，母亲4-OH-CB107浓度处于上四分位数的新生儿出生体重比浓度处于最低四分位数的新生儿轻316克（95%置信区间（CI）566, 65）。这种关联在不吸烟母亲中未观察到，也不是由母亲甲状腺激素水平介导的。母亲孕期4-OH-CB107水平似乎受母亲吸烟影响，并导致吸烟者的新生儿出生体重降低。
