Castel Guillaume, Tordo Noël, Plyusnin Alexander
INRA-UMR 1062 CBGP, 755 Avenue Campus Agropolis, CS30016, 34988 Montferrier sur Lez, France.
Unit Antiviral Strategies, Institut Pasteur, 25 Rue du Dr Roux, 75724 Paris Cedex 15, France; Institut Pasteur de Guinée, Gamal Abdel Nasser University, Conakry, Guinea.
Virus Res. 2017 Apr 2;233:60-69. doi: 10.1016/j.virusres.2017.03.011. Epub 2017 Mar 16.
Because of the great variability of their reservoir hosts, hantaviruses are excellent models to evaluate the dynamics of virus-host co-evolution. Intriguing questions remain about the timescale of the diversification events that influenced this evolution. In this paper we attempted to estimate the first ever timing of hantavirus diversification based on thirty five available complete genomes representing five major groups of hantaviruses and the assumption of co-speciation of hantaviruses with their respective mammal hosts. Phylogenetic analyses were used to estimate the main diversification points during hantavirus evolution in mammals while host diversification was mostly estimated from independent calibrators taken from fossil records. Our results support an earlier developed hypothesis of co-speciation of known hantaviruses with their respective mammal hosts and hence a common ancestor for all hantaviruses carried by placental mammals.
由于其储存宿主的高度变异性，汉坦病毒是评估病毒与宿主共同进化动态的优秀模型。关于影响这种进化的多样化事件的时间尺度，仍存在一些有趣的问题。在本文中，我们试图基于代表汉坦病毒五个主要组的35个可用完整基因组以及汉坦病毒与其各自哺乳动物宿主共物种形成的假设，首次估计汉坦病毒多样化的时间。系统发育分析用于估计汉坦病毒在哺乳动物中进化过程中的主要多样化点，而宿主多样化主要从化石记录中的独立校准器估计。我们的结果支持了一个早期提出的假设，即已知汉坦病毒与其各自哺乳动物宿主共物种形成，因此胎盘哺乳动物携带的所有汉坦病毒有一个共同祖先。
