Allarakia Sabah, Khayat Hassan A, Karami Moyassar M, Aldakhil Abdulaziz M, Kashi Ahmed M, Algain Abdulrahman H, Khan Mohammad A, Alghifees Loai S, Alsulami Raed E
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J Perinat Med. 2017 Dec 20;45(9):1013-1021. doi: 10.1515/jpm-2016-0422.
To describe the clinical features of mirror syndrome and to correlate the effects of different treatments with the fetal outcomes.
Online search up to May 2016 was conducted in the PubMed, Embase (Ovid platform) and clinicalTrials.gov without restrictions of language, date or journal. Only papers providing both fetal and maternal presentations and outcomes were included.
The study included 74 papers (n=111), with an additional two patients diagnosed at our center (n=113). The mean gestational age at diagnosis was 27 weeks±30 days (16-39 weeks). Whether early or late gestational age at diagnosis, and whether mother and fetus show symptoms simultaneously or on different dates, has insignificant impact on fetal outcome (P=0.06 and P=0.46, respectively). Edema (84%) followed by hypertension (60.1%) were the leading maternal findings. Fetal hydrops (94.7%) and placental edema (62.8%) were the commonest sonographic features. Procedures correcting fetal hydrops/anemia in utero as well as labor induction were the only treatment options correlated with improved fetal survival (χ2 analysis, P=0.01 and Fisher's exact test, P=0.02; respectively). The overall rate of fetal/neonatal mortality was 67.26%.
The gestational age at diagnosis and sequence of presentation have insignificant impact on fetal outcome. Improved fetal survival was associated with procedural interventions that correct fetal hydrops as well as labor induction.
描述镜像综合征的临床特征，并将不同治疗方法的效果与胎儿结局相关联。
截至2016年5月，在PubMed、Embase（Ovid平台）和ClinicalTrials.gov上进行了不限语言、日期或期刊的在线搜索。仅纳入提供胎儿和母亲表现及结局的论文。
该研究纳入了74篇论文（n = 111），另外在我们中心诊断出2例患者（n = 113）。诊断时的平均孕周为27周±30天（16 - 39周）。诊断时孕周早或晚，以及母亲和胎儿是同时还是在不同日期出现症状，对胎儿结局均无显著影响（分别为P = 0.06和P = 0.46）。母亲的主要表现为水肿（84%），其次是高血压（60.1%）。胎儿水肿（94.7%）和胎盘水肿（62.8%）是最常见的超声特征。宫内纠正胎儿水肿/贫血的操作以及引产是与改善胎儿存活率相关的唯一治疗选择（χ²分析，P = 0.01；Fisher精确检验，P = 0.02）。胎儿/新生儿总体死亡率为67.26%。
诊断时的孕周和表现顺序对胎儿结局无显著影响。改善胎儿存活率与纠正胎儿水肿的操作干预以及引产有关。
