Neff Guy W, Jayaweera Dushyantha, Sherman Kenneth E
Dr. Neff serves as Medical Director of Liver Transplantation and Dr. Sherman is Program Director in the Department of Medicine at the University of Cincinnati. Dr. Jayaweera is in the Department of Medicine at the University of Miami.
Gastroenterol Hepatol (N Y). 2006 Jun;2(6):430-437.
The treatment of HIV has improved over the last decade due in part to the success of treatment with combination-therapy drug "cocktails," better referred to as highly active antiretroviral therapy. The safety and efficacy of these regimens is often complicated by the presence of infectious hepatitis and occurrence of drug-induced liver injury. In most patients, these complications manifest as mild laboratory abnormalities and exist without clinical consequence. However, acute and chronic hepatic injury may lead to increased morbidity and mortality. It is essential to identify all potential causes of liver injury to correctly implement steps to alleviate the condition while maintaining optimal control of HIV viremia.
在过去十年中，艾滋病毒的治疗有所改善，部分原因是联合治疗药物“鸡尾酒疗法”（更确切地说是高效抗逆转录病毒疗法）取得了成功。这些治疗方案的安全性和有效性常常因感染性肝炎的存在和药物性肝损伤的发生而变得复杂。在大多数患者中，这些并发症表现为轻微的实验室异常，且没有临床后果。然而，急性和慢性肝损伤可能导致发病率和死亡率增加。识别肝损伤的所有潜在原因对于在维持对艾滋病毒血症的最佳控制的同时正确实施缓解病情的措施至关重要。
