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人羊膜:在口腔及牙周领域的潜在应用

Human Amnion Membrane: Potential Applications in Oral and Periodontal Field.

作者信息

Mohan Ranjana, Bajaj Aashima, Gundappa Mohan

机构信息

Department of Periodontics, Teerthanker Mahaveer Dental College and Research Centre, Moradabad, Uttar Pradesh, India.

Department of Conservative Dentistry and Endodontics, Teerthanker Mahaveer Dental College and Research Centre, Moradabad, Uttar Pradesh, India.

出版信息

J Int Soc Prev Community Dent. 2017 Jan-Feb;7(1):15-21. doi: 10.4103/jispcd.JISPCD_359_16. Epub 2017 Feb 21.

DOI:10.4103/jispcd.JISPCD_359_16
PMID:28316944
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5343678/
Abstract

Human amniotic membrane (HAM) is derived from the fetal membranes which consist of the inner amniotic membrane made of single layer of amnion cells fixed to collagen-rich mesenchyme attached to chorion. HAM has low immunogenicity, anti-inflammatory properties and their cells can be isolated without the sacrifice of human embryos. Amniotic membrane has biological properties which are important for the experimental and clinical applications in managing patients of various medical specialties. Abundant, natural and wonderful biomembrane not only protects the foetus but also has various clinical applications in the field of dermatology, ophthalmology, ENT surgery, orthopedics and dental surgery. As it is discarded post-partum it may be useful for regenerative medicine and cell therapy to treat damaged or diseased tissues.

摘要

人羊膜(HAM)源自胎膜,胎膜由内层羊膜组成,内层羊膜由单层羊膜细胞构成,这些细胞附着于富含胶原蛋白的间充质上,而间充质又附着于绒毛膜。HAM具有低免疫原性、抗炎特性,并且可以分离其细胞而无需牺牲人类胚胎。羊膜具有生物学特性,这些特性对于各个医学专业治疗患者的实验和临床应用都很重要。这种丰富、天然且出色的生物膜不仅能保护胎儿,还在皮肤科、眼科、耳鼻喉科手术、骨科和牙科手术领域有多种临床应用。由于它在产后被丢弃,可能对再生医学和细胞治疗受损或患病组织有用。

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本文引用的文献

1
Amniotic membrane - A Novel material for the root coverage: A case series.羊膜——一种用于牙根覆盖的新型材料:病例系列
J Indian Soc Periodontol. 2015 Jul-Aug;19(4):444-8. doi: 10.4103/0972-124X.154166.
2
Human amniotic membrane transplantation: Different modalities of its use in ophthalmology.人羊膜移植:其在眼科应用的不同方式。
World J Transplant. 2014 Jun 24;4(2):111-21. doi: 10.5500/wjt.v4.i2.111.
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Clinical application of a hyperdry amniotic membrane on surgical defects of the oral mucosa.超干燥羊膜在口腔黏膜手术缺损中的临床应用。
J Oral Maxillofac Surg. 2012 Sep;70(9):2221-8. doi: 10.1016/j.joms.2011.09.033. Epub 2011 Dec 22.
4
Differentiation factors that influence neuronal markers expression in vitro from human amniotic epithelial cells.影响人羊膜上皮细胞体外神经元标志物表达的分化因素。
Eur Cell Mater. 2010 Jan 14;19:22-9. doi: 10.22203/ecm.v019a03.
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Repair of oronasal fistulas with human amniotic membrane in minipigs.
Br J Oral Maxillofac Surg. 2010 Mar;48(2):131-5. doi: 10.1016/j.bjoms.2009.04.025. Epub 2009 May 23.
6
A clinical and radiological evaluation of DFDBA with amniotic membrane versus bovine derived xenograft with amniotic membrane in human periodontal grade II furcation defects.人牙周Ⅱ度根分叉病变中,脱矿冻干骨与羊膜联合应用对比牛源性异种移植物与羊膜联合应用的临床及影像学评估
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Human fetal membranes: a source of stem cells for tissue regeneration and repair?人胎膜:组织再生与修复的干细胞来源?
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In vivo laser confocal microscopy findings of cryopreserved and fresh human amniotic membrane.
Ophthalmic Surg Lasers Imaging. 2008 Jul-Aug;39(4):312-8. doi: 10.3928/15428877-20080701-10.
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The advantages of the application of amnion membrane in the treatment of burns.羊膜在烧伤治疗中的应用优势。
Prilozi. 2008 Jul;29(1):183-98.
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Immunogenicity and immunomodulatory effects of amnion-derived multipotent progenitor cells.羊膜来源的多能祖细胞的免疫原性和免疫调节作用。
Hum Immunol. 2008 Jun;69(6):321-8. doi: 10.1016/j.humimm.2008.04.007. Epub 2008 May 15.