Olose Emmanuel Omamurhomu, Edet John, Igwe Monday Nwite, Chukwujekwu Donald Chidozie, Aguocha Miriam Chinyere, Uwakwe Richard
Department of Psychiatry, University of Calabar, Calabar, Nigeria.
Department of Clinical Services, Federal Neuropsychiatric Hospital, Calabar, Nigeria.
Psychiatry J. 2017;2017:9410575. doi: 10.1155/2017/9410575. Epub 2017 Feb 20.
. Determine association between use (and type) of antipsychotics and dyslipidaemia in newly diagnosed schizophrenia patients attending Federal Neuropsychiatric Hospital, Enugu. . From sixty antipsychotic naive patients with schizophrenia and sixty first-degree relatives matched for gender and age, fasting blood lipid profiles were measured at baseline and after twelve weeks. Medical Outcome Study Short Form General Health Survey was administered to patients on both occasions. Fasting lipid profile changes of both groups were compared. . Mean endpoint of total cholesterol (TC), low density lipoprotein (LD), and triglycerides (TG) in mmol/l for cases was significantly higher than initial values (TC 4.5 versus 4.3, = 4.3, < 0.0001), (LDL 2.8 versus 2.6, = 14.3, < 0.0001), and (TG 1.3 versus 1.0, = 12.1, < 0.0001). Mean endpoint of high density lipoprotein (HDL) in mmol/l for cases was significantly lower than initial values (1.1 versus 1.2, = 12.1, < 0.0001). Prevalence of dyslipidaemia for cases was 13%. Mean endpoint of TC, LDL, TG, and HDL in mmol/l for controls was not significantly different from initial values (TC 4.30 versus 4.27, = 1.09, = 0.279), (LDL 2.49 versus 2.46, = 1.28, = 0.205), (TG 0.96 versus 0.94, = 1.27, = 0.207), and (HDL 1.37 versus 1.38, = 1.61, = 0.113). Subjects on atypical antipsychotics had higher risk for dyslipidaemia. . Use of antipsychotics was significantly associated with dyslipidaemia.
确定在埃努古联邦神经精神病医院就诊的新诊断精神分裂症患者中抗精神病药物的使用（及类型）与血脂异常之间的关联。从60名未使用过抗精神病药物的精神分裂症患者以及60名年龄和性别匹配的一级亲属中，在基线和12周后测量空腹血脂谱。在这两个时间点都对患者进行医学结局研究简短形式一般健康调查。比较两组的空腹血脂谱变化。病例组总胆固醇（TC）、低密度脂蛋白（LD）和甘油三酯（TG）的平均终点值（单位：mmol/l）显著高于初始值（TC：4.5对4.3，t = 4.3，p < 0.0001），（LDL：2.8对2.6，t = 14.3，p < 0.0001），以及（TG：1.3对1.0，t = 12.1，p < 0.0001）。病例组高密度脂蛋白（HDL）的平均终点值（单位：mmol/l）显著低于初始值（1.1对1.2，t = 12.1，p < 0.0001）。病例组血脂异常的患病率为13%。对照组TC、LDL、TG和HDL的平均终点值（单位：mmol/l）与初始值无显著差异（TC：4.30对4.27，t = 1.09，p = 0.279），（LDL：2.49对2.46，t = 1.28，p = 0.205），（TG：0.96对0.94，t = 1.27，p = 0.207），以及（HDL：1.37对1.38，t = 1.61，p = 0.113）。使用非典型抗精神病药物的受试者患血脂异常的风险更高。抗精神病药物的使用与血脂异常显著相关。
