Herget Ulrich, Gutierrez-Triana Jose Arturo, Salazar Thula Oriana, Knerr Boris, Ryu Soojin
Developmental Genetics of the Nervous System, Max Planck Institute for Medical Research , 69120 Heidelberg, Germany.
Developmental Genetics of the Nervous System, Max Planck Institute for Medical Research, 69120 Heidelberg, Germany; Focus Program Translational Neuroscience, University Medical Center, Johannes Gutenberg University Mainz, Langenbeckstr. 1, 55131, Mainz, Germany.
eNeuro. 2017 Feb 8;4(1). doi: 10.1523/ENEURO.0278-16.2016. eCollection 2017 Jan-Feb.
Oxytocin regulates a diverse set of processes including stress, analgesia, metabolism, and social behavior. How such diverse functions are mediated by a single hormonal system is not well understood. Different functions of oxytocin could be mediated by distinct cell groups, yet it is currently unknown whether different oxytocinergic cell types exist that specifically mediate peripheral neuroendocrine or various central neuromodulatory processes via dedicated pathways. Using the Brainbow technique to map the morphology and projections of individual oxytocinergic cells in the larval zebrafish brain, we report here the existence of two main types of oxytocinergic cells: those that innervate the pituitary and those that innervate diverse brain regions. Similar to the situation in the adult rat and the adult midshipman, but in contrast to the situation in the adult trout, these two cell types are mutually exclusive and can be distinguished based on morphological and anatomical criteria. Further, our results reveal that complex oxytocinergic innervation patterns are already established in the larval zebrafish brain.
催产素调节一系列不同的生理过程，包括应激、镇痛、新陈代谢和社会行为。单一的激素系统如何介导如此多样的功能，目前还不太清楚。催产素的不同功能可能由不同的细胞群介导，但目前尚不清楚是否存在不同的催产素能细胞类型，它们通过特定途径专门介导外周神经内分泌或各种中枢神经调节过程。利用Brainbow技术绘制斑马鱼幼体大脑中单个催产素能细胞的形态和投射，我们在此报告存在两种主要类型的催产素能细胞：那些支配垂体的细胞和那些支配不同脑区的细胞。与成年大鼠和成年海蟾蜍的情况类似，但与成年鳟鱼的情况不同，这两种细胞类型相互排斥，并且可以根据形态学和解剖学标准加以区分。此外，我们的结果表明，复杂的催产素能神经支配模式在斑马鱼幼体大脑中已经建立。
