Meyer Tjark H, Liu Weiping, Feldt Milica, Wuttke Axel, Mata Ricardo A, Ackermann Lutz
Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tammannstraße 2, 37077, Gottingen, Germany.
Institut für Physikalische Chemie, Georg-August-Universität Göttingen, Tammannstraße 6, 37077, Gottingen, Germany.
Chemistry. 2017 Apr 24;23(23):5443-5447. doi: 10.1002/chem.201701191. Epub 2017 Apr 3.
C-H/C-C Functionalizations were achieved with the aid of a versatile manganese(I) catalyst. Thus, an organometallic manganese-catalyzed C-H activation set the stage for silver-free C-H/C-C transformations with ample substrate scope and excellent levels of chemo-, site-, and diastereo-selectivities. The robust nature of the manganese(I) catalysis regime was reflected by the first C-H/C-C functionalization on amino acids under racemization-free reaction conditions. Detailed experimental and computational mechanistic studies provided strong evidence for a facile C-H activation and a rate-determining C-C cleavage, with considerable contribution from London dispersion interactions.
借助通用的锰（I）催化剂实现了C-H/C-C官能团化。因此，有机金属锰催化的C-H活化开启了无银C-H/C-C转化的篇章，该转化具有广泛的底物范围以及出色的化学、位点和非对映选择性。锰（I）催化体系的稳健性体现在氨基酸在无消旋化反应条件下的首次C-H/C-C官能团化上。详细的实验和计算机理研究为容易的C-H活化和决速的C-C裂解提供了有力证据，伦敦色散相互作用也有相当大的贡献。
