Zell Daniel, Müller Valentin, Dhawa Uttam, Bursch Markus, Presa Rubén Rubio, Grimme Stefan, Ackermann Lutz
Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tammannstraße 2, 37077, Göttingen, Germany.
Mulliken Center for Theoretical Chemistry, Institut für Physikalische und Theoretische Chemie, Universität Bonn, Beringstraße 4, 53115, Bonn, Germany.
Chemistry. 2017 Sep 7;23(50):12145-12148. doi: 10.1002/chem.201702528. Epub 2017 Jul 31.
Sustainable, cobalt-catalyst enabled, synthetically significant C-F/C-H functionalizations were achieved with an ample substrate scope at an ambient temperature of 25 °C, thereby delivering perfluoroallylated heteroarenes. Detailed experimental and computational mechanistic studies on the C-F/C-H functionalizations provided strong support for a facile C-F cleavage.
在25°C的环境温度下，实现了可持续的、由钴催化剂促成的、具有合成重要性的C-F/C-H官能团化反应，底物范围广泛，从而得到全氟烯丙基化的杂芳烃。对C-F/C-H官能团化反应进行的详细实验和计算机理研究为C-F的轻松裂解提供了有力支持。
