Wei Wei, Leng Jiangyong, Shao Hongxiang, Wang Weidong
Department of Urinary Surgery, Ningbo No.2 Hospital, Ningbo City, Zhejiang Province, China.
Department of Urinary Surgery, Ningbo No.2 Hospital, Ningbo City, Zhejiang Province, China.
Am J Med Sci. 2017 Apr;353(4):315-319. doi: 10.1016/j.amjms.2017.01.006. Epub 2017 Jan 31.
Increasing evidence suggests that aberrant microRNAs expressions are significantly associated with cancer progression. Previous studies have reported that the relative expression of miR-1 is significantly downregulated in recurrent prostate cancer (PCa) samples when compared with nonrecurrent PCa tissues. However, whether miR-1 can serve as a novel predictive biomarker for PCa recurrence still remains unclear.
The patients with clinically localized PCa who underwent radical prostatectomy by the same medical team at the Department of Urology, Ningbo No.2 Hospital were enrolled in this study. We examined the miR-1 expression levels in recurrent and nonrecurrent tumor samples by quantitative reverse transcription polymerase chain reaction. Univariate and multivariate Cox proportional hazards analyses were used for the evaluation of potential predictors of PCa recurrence.
During the study period, 78 patients (including 27 in the recurrent group and 51 in the nonrecurrent group) who were diagnosed with PCa and who underwent radical prostatectomy were included in the final analysis. MiR-1 was significantly downregulated in recurrent PCa tissues when compared with nonrecurrent tumor samples (P < 0.001). The univariate and multivariate Cox proportional hazards analyses indicated that miR-1 was the only independent prognostic factor for PCa recurrence (hazard ratio = 1.86; 95% CI: 1.21-2.94; P = 0.011). The area under the curve value of miR-1 for PCa recurrence was 0.885 (P < 0.001) with the sensitivity of 0.863 and specificity of 0.889 based on receiver operating characteristic curve analysis.
This study identifies that miR-1 in PCa tissues can function as an important independent predictive factor for PCa recurrence.
越来越多的证据表明，异常的微小RNA表达与癌症进展显著相关。先前的研究报道，与非复发性前列腺癌组织相比，复发性前列腺癌（PCa）样本中miR-1的相对表达显著下调。然而，miR-1是否可作为PCa复发的新型预测生物标志物仍不清楚。
本研究纳入了宁波市第二医院泌尿外科同一医疗团队进行根治性前列腺切除术的临床局限性PCa患者。我们通过定量逆转录聚合酶链反应检测复发性和非复发性肿瘤样本中的miR-1表达水平。采用单因素和多因素Cox比例风险分析来评估PCa复发的潜在预测因素。
在研究期间，最终分析纳入了78例被诊断为PCa并接受根治性前列腺切除术的患者（包括复发组27例和非复发组51例）。与非复发性肿瘤样本相比，复发性PCa组织中miR-1显著下调（P < 0.001）。单因素和多因素Cox比例风险分析表明，miR-1是PCa复发的唯一独立预后因素（风险比 = 1.86；95% CI：1.21 - 2.94；P = 0.011）。基于受试者工作特征曲线分析，miR-1预测PCa复发的曲线下面积值为0.885（P < 0.001），敏感性为0.863，特异性为0.889。
本研究表明，PCa组织中的miR-1可作为PCa复发的重要独立预测因素。
