Bevacqua Emilia, Ammirato Salvatore, Cione Erika, Curcio Rosita, Dolce Vincenza, Tucci Paola
Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy.
Department of Mechanical, Energy and Management Engineering, University of Calabria, 87036 Rende, Italy.
Cancers (Basel). 2022 Nov 3;14(21):5418. doi: 10.3390/cancers14215418.
Prostate cancer (PCa) is the second leading cause of cancer-related deaths in men. Although the prostate-specific antigen (PSA) test is used in clinical practice for screening and/or early detection of PCa, it is not specific, thus resulting in high false-positive rates. MicroRNAs (miRs) provide an opportunity as biomarkers for diagnosis, prognosis, and recurrence of PCa. Because the size of the literature on it is increasing and often controversial, this study aims to consolidate the state-of-art of relevant published research. A Systematic Literature Review (SLR) approach was applied to analyze a set of 213 scientific publications through a text mining method that makes use of the Latent Dirichlet Allocation (LDA) algorithm. The result of this activity, performed through the MySLR digital platform, allowed us to identify a set of three relevant topics characterizing the investigated research area. We analyzed and discussed all the papers clustered into them. We highlighted that several miRs are associated with PCa progression, and that their detection in patients' urine seems to be the more reliable and promising non-invasive tool for PCa diagnosis. Finally, we proposed some future research directions to help future scientists advance the field further.
前列腺癌（PCa）是男性癌症相关死亡的第二大主要原因。尽管前列腺特异性抗原（PSA）检测在临床实践中用于前列腺癌的筛查和/或早期检测，但它并不具有特异性，因此导致高假阳性率。微小RNA（miRs）为前列腺癌的诊断、预后和复发提供了作为生物标志物的机会。由于关于它的文献数量不断增加且常常存在争议，本研究旨在整合相关已发表研究的最新进展。采用系统文献综述（SLR）方法，通过利用潜在狄利克雷分配（LDA）算法的文本挖掘方法，对213篇科学出版物进行分析。通过MySLR数字平台开展的这项活动的结果，使我们能够确定表征所研究领域的一组三个相关主题。我们对归入这些主题的所有论文进行了分析和讨论。我们强调，几种miRs与前列腺癌进展相关，并且在患者尿液中检测它们似乎是前列腺癌诊断中更可靠且有前景的非侵入性工具。最后，我们提出了一些未来的研究方向，以帮助未来的科学家进一步推动该领域的发展。
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