• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

家猪不太可能是中东呼吸综合征冠状病毒的贮存宿主。

Domestic Pig Unlikely Reservoir for MERS-CoV.

出版信息

Emerg Infect Dis. 2017 Jun;23(6):985-988. doi: 10.3201/eid2306.170096. Epub 2017 Jun 15.

DOI:10.3201/eid2306.170096
PMID:28318484
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5443456/
Abstract

We tested the suitability of the domestic pig as a model for Middle East respiratory syndrome coronavirus (MERS-CoV) infection. Inoculation did not cause disease, but a low level of virus replication, shedding, and seroconversion were observed. Pigs do not recapitulate human MERS-CoV and are unlikely to constitute a reservoir in nature.

摘要

我们测试了家猪作为中东呼吸综合征冠状病毒(MERS-CoV)感染模型的适用性。接种不会引起疾病,但观察到低水平的病毒复制、脱落和血清转化。猪不能重现人类 MERS-CoV,并且不太可能在自然界中构成储主。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0fc/5443456/05749f98457e/17-0096-F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0fc/5443456/98b31a94a8f6/17-0096-F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0fc/5443456/05749f98457e/17-0096-F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0fc/5443456/98b31a94a8f6/17-0096-F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0fc/5443456/05749f98457e/17-0096-F2.jpg

相似文献

1
Domestic Pig Unlikely Reservoir for MERS-CoV.家猪不太可能是中东呼吸综合征冠状病毒的贮存宿主。
Emerg Infect Dis. 2017 Jun;23(6):985-988. doi: 10.3201/eid2306.170096. Epub 2017 Jun 15.
2
Livestock Susceptibility to Infection with Middle East Respiratory Syndrome Coronavirus.家畜对中东呼吸综合征冠状病毒感染的易感性。
Emerg Infect Dis. 2017 Feb;23(2):232-240. doi: 10.3201/eid2302.161239. Epub 2017 Feb 15.
3
Middle East respiratory syndrome coronavirus experimental transmission using a pig model.利用猪模型进行中东呼吸综合征冠状病毒的实验性传播
Transbound Emerg Dis. 2017 Oct;64(5):1342-1345. doi: 10.1111/tbed.12668. Epub 2017 Jun 26.
4
Permissivity of Dipeptidyl Peptidase 4 Orthologs to Middle East Respiratory Syndrome Coronavirus Is Governed by Glycosylation and Other Complex Determinants.二肽基肽酶4直系同源物对中东呼吸综合征冠状病毒的易感性受糖基化和其他复杂决定因素的调控。
J Virol. 2017 Sep 12;91(19). doi: 10.1128/JVI.00534-17. Print 2017 Oct 1.
5
Co-localization of Middle East respiratory syndrome coronavirus (MERS-CoV) and dipeptidyl peptidase-4 in the respiratory tract and lymphoid tissues of pigs and llamas.中东呼吸综合征冠状病毒(MERS-CoV)在猪和美洲驼呼吸道和淋巴组织中的共定位。
Transbound Emerg Dis. 2019 Mar;66(2):831-841. doi: 10.1111/tbed.13092. Epub 2018 Dec 28.
6
Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia.沙特阿拉伯三种骆驼冠状病毒的共同循环和 MERS-CoV 的重组。
Science. 2016 Jan 1;351(6268):81-4. doi: 10.1126/science.aac8608. Epub 2015 Dec 17.
7
Bactrian camels shed large quantities of Middle East respiratory syndrome coronavirus (MERS-CoV) after experimental infection.双峰驼在感染中东呼吸综合征冠状病毒(MERS-CoV)后的大量脱落。
Emerg Microbes Infect. 2019;8(1):717-723. doi: 10.1080/22221751.2019.1618687.
8
Generation of a transgenic mouse model of Middle East respiratory syndrome coronavirus infection and disease.中东呼吸综合征冠状病毒感染与疾病转基因小鼠模型的建立。
J Virol. 2015 Apr;89(7):3659-70. doi: 10.1128/JVI.03427-14. Epub 2015 Jan 14.
9
Inoculation of Goats, Sheep, and Horses with MERS-CoV Does Not Result in Productive Viral Shedding.用中东呼吸综合征冠状病毒接种山羊、绵羊和马不会导致病毒有效排出。
Viruses. 2016 Aug 19;8(8):230. doi: 10.3390/v8080230.
10
Coronavirus Host Range Expansion and Middle East Respiratory Syndrome Coronavirus Emergence: Biochemical Mechanisms and Evolutionary Perspectives.冠状病毒宿主范围扩张和中东呼吸综合征冠状病毒出现:生化机制和进化视角。
Annu Rev Virol. 2015 Nov;2(1):95-117. doi: 10.1146/annurev-virology-100114-055029. Epub 2015 Aug 7.

引用本文的文献

1
One Health and Cattle Genetic Resources: Mining More than 500 Cattle Genomes to Identify Variants in Candidate Genes Potentially Affecting Coronavirus Infections.同一健康与牛遗传资源:挖掘500多个牛基因组以鉴定可能影响冠状病毒感染的候选基因中的变异。
Animals (Basel). 2022 Mar 26;12(7):838. doi: 10.3390/ani12070838.
2
SARS-CoV-2 in animals: From potential hosts to animal models.动物中的 SARS-CoV-2:从潜在宿主到动物模型。
Adv Virus Res. 2021;110:59-102. doi: 10.1016/bs.aivir.2021.03.004. Epub 2021 Apr 7.
3
Host Diversity and Potential Transmission Pathways of SARS-CoV-2 at the Human-Animal Interface.

本文引用的文献

1
Livestock Susceptibility to Infection with Middle East Respiratory Syndrome Coronavirus.家畜对中东呼吸综合征冠状病毒感染的易感性。
Emerg Infect Dis. 2017 Feb;23(2):232-240. doi: 10.3201/eid2302.161239. Epub 2017 Feb 15.
2
A Comparative Review of Animal Models of Middle East Respiratory Syndrome Coronavirus Infection.中东呼吸综合征冠状病毒感染动物模型的比较综述
Vet Pathol. 2016 May;53(3):521-31. doi: 10.1177/0300985815620845. Epub 2016 Feb 11.
3
Clinicopathologic, Immunohistochemical, and Ultrastructural Findings of a Fatal Case of Middle East Respiratory Syndrome Coronavirus Infection in the United Arab Emirates, April 2014.
人类与动物界面处SARS-CoV-2的宿主多样性及潜在传播途径
Pathogens. 2021 Feb 8;10(2):180. doi: 10.3390/pathogens10020180.
4
Comparative tropism, replication kinetics, and cell damage profiling of SARS-CoV-2 and SARS-CoV with implications for clinical manifestations, transmissibility, and laboratory studies of COVID-19: an observational study.SARS-CoV-2 和 SARS-CoV 的比较嗜性、复制动力学和细胞损伤特征分析及其对 COVID-19 临床表现、传染性和实验室研究的影响:一项观察性研究。
Lancet Microbe. 2020 May;1(1):e14-e23. doi: 10.1016/S2666-5247(20)30004-5. Epub 2020 Apr 21.
5
A Comprehensive Review of Animal Models for Coronaviruses: SARS-CoV-2, SARS-CoV, and MERS-CoV.冠状病毒动物模型的全面综述:SARS-CoV-2、SARS-CoV 和 MERS-CoV。
Virol Sin. 2020 Jun;35(3):290-304. doi: 10.1007/s12250-020-00252-z. Epub 2020 Jun 30.
6
Development of a Mouse-Adapted MERS Coronavirus.一种适应小鼠的中东呼吸综合征冠状病毒的研制
Methods Mol Biol. 2020;2099:161-171. doi: 10.1007/978-1-0716-0211-9_13.
7
Detection of MERS-CoV antigen on formalin-fixed paraffin-embedded nasal tissue of alpacas by immunohistochemistry using human monoclonal antibodies directed against different epitopes of the spike protein.使用针对刺突蛋白不同表位的人源单克隆抗体,通过免疫组织化学方法在福尔马林固定石蜡包埋的羊驼鼻组织上检测中东呼吸综合征冠状病毒抗原。
Vet Immunol Immunopathol. 2019 Dec;218:109939. doi: 10.1016/j.vetimm.2019.109939. Epub 2019 Sep 9.
8
Species-Specific Colocalization of Middle East Respiratory Syndrome Coronavirus Attachment and Entry Receptors.特定种属中东呼吸综合征冠状病毒附着和进入受体的共定位。
J Virol. 2019 Jul 30;93(16). doi: 10.1128/JVI.00107-19. Print 2019 Aug 15.
9
Bactrian camels shed large quantities of Middle East respiratory syndrome coronavirus (MERS-CoV) after experimental infection.双峰驼在感染中东呼吸综合征冠状病毒(MERS-CoV)后的大量脱落。
Emerg Microbes Infect. 2019;8(1):717-723. doi: 10.1080/22221751.2019.1618687.
10
Host Determinants of MERS-CoV Transmission and Pathogenesis.中东呼吸综合征冠状病毒的宿主决定因素与发病机制。
Viruses. 2019 Mar 19;11(3):280. doi: 10.3390/v11030280.
2014年4月阿拉伯联合酋长国中东呼吸综合征冠状病毒感染致死病例的临床病理、免疫组织化学及超微结构研究结果
Am J Pathol. 2016 Mar;186(3):652-8. doi: 10.1016/j.ajpath.2015.10.024. Epub 2016 Feb 5.
4
Animal models of Middle East respiratory syndrome coronavirus infection.中东呼吸综合征冠状病毒感染的动物模型
Antiviral Res. 2015 Oct;122:28-38. doi: 10.1016/j.antiviral.2015.07.005. Epub 2015 Jul 17.
5
Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques.中东呼吸综合征冠状病毒(MERS-CoV)可导致恒河猴一过性下呼吸道感染。
Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16598-603. doi: 10.1073/pnas.1310744110. Epub 2013 Sep 23.
6
Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4.MERS-CoV 刺突受体结合域与人受体 DPP4 复合物的结构。
Cell Res. 2013 Aug;23(8):986-93. doi: 10.1038/cr.2013.92. Epub 2013 Jul 9.
7
Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26.新型人类冠状病毒 MERS-CoV 与其受体 CD26 结合的分子基础。
Nature. 2013 Aug 8;500(7461):227-31. doi: 10.1038/nature12328. Epub 2013 Jul 7.
8
Pneumonia from human coronavirus in a macaque model.猕猴模型中人类冠状病毒引起的肺炎
N Engl J Med. 2013 Apr 18;368(16):1560-2. doi: 10.1056/NEJMc1215691. Epub 2013 Apr 3.
9
Human coronavirus EMC does not require the SARS-coronavirus receptor and maintains broad replicative capability in mammalian cell lines.人冠状病毒 EMC 并不需要 SARS 冠状病毒受体,并且在哺乳动物细胞系中保持广泛的复制能力。
mBio. 2012 Dec 11;3(6):e00515-12. doi: 10.1128/mBio.00515-12.
10
Detection of a novel human coronavirus by real-time reverse-transcription polymerase chain reaction.实时逆转录聚合酶链反应检测新型人类冠状病毒。
Euro Surveill. 2012 Sep 27;17(39):20285. doi: 10.2807/ese.17.39.20285-en.