Claborn Kasey, Miller Mary Beth, Meier Ellen, Carbone Sofia
J Assoc Nurses AIDS Care. 2017 Jul-Aug;28(4):479-490. doi: 10.1016/j.jana.2017.02.008. Epub 2017 Mar 3.
Treatment regimen fatigue (TRF) is a decreased desire and motivation to maintain vigilance in adhering to treatment, and little is known about TRF in people living with HIV. We aimed to develop a conceptual framework of TRF. Five focus groups were conducted in 2014. Eligible participants were (a) HIV infected, (b) at least 18 years of age, (c) prescribed antiretroviral therapy, and (d) fluent in English. Data were analyzed using thematic analysis. Analyses revealed these themes: patient experiences of TRF; etiological factors at the systems, provider, and patient levels; strategies to manage TRF; consequences of TRF; and protective factors that prevent the occurrence of TRF. The results provided a conceptual framework for future investigations to build on in an effort to improve adherence and retention in HIV care. Study results indicate avenues for intervention at multiple levels (systems, provider, and patient) to reduce treatment burden and improve patient resources and capacity.
治疗方案疲劳（TRF）是指在坚持治疗过程中保持警惕的欲望和动力下降，而对于感染艾滋病毒的人群中的治疗方案疲劳情况，人们了解甚少。我们旨在构建一个治疗方案疲劳的概念框架。2014年开展了五次焦点小组讨论。符合条件的参与者为：（a）感染艾滋病毒；（b）至少18岁；（c）正在接受抗逆转录病毒治疗；（d）英语流利。采用主题分析法对数据进行分析。分析揭示了以下主题：治疗方案疲劳的患者体验；系统、医疗服务提供者和患者层面的病因因素；应对治疗方案疲劳的策略；治疗方案疲劳的后果；以及预防治疗方案疲劳发生的保护因素。研究结果为未来的调查提供了一个概念框架，以便在此基础上努力提高艾滋病毒护理的依从性和持续性。研究结果表明了在多个层面（系统、医疗服务提供者和患者）进行干预的途径，以减轻治疗负担并改善患者资源和能力。
