Goli Navya, Mainkar Prathama S, Kotapalli Sudha Sravanti, K Tejaswini, Ummanni Ramesh, Chandrasekhar Srivari
Division of Natural Product Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India; Academy of Scientific and Innovative Research, New Delhi, India.
Medicinal Chemistry and Pharmacology Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India.
Bioorg Med Chem Lett. 2017 Apr 15;27(8):1714-1720. doi: 10.1016/j.bmcl.2017.02.077. Epub 2017 Mar 6.
Tetrahydroquinoline is a privileged scaffold with a large number of biological applications. The tetrahydroquinoline pharmacophore has been expanded to yield 34 compounds. Biological screening of these compounds led to the identification of tetrahydroquinoline as neurotropic agents not reported earlier.
四氢喹啉是一种具有大量生物学应用的优势骨架。四氢喹啉药效基团已得到扩展，从而产生了34种化合物。对这些化合物的生物学筛选导致鉴定出四氢喹啉为先前未报道的嗜神经药。
