肢体预模式的双域假说及其与先天性肢体异常的相关性。
The two domain hypothesis of limb prepattern and its relevance to congenital limb anomalies.
作者信息
Tao Hirotaka, Kawakami Yasuhiko, Hui Chi-Chung, Hopyan Sevan
机构信息
Program in Developmental and Stem Cell Biology, Research Institute, The Hospital for Sick Children, Toronto, Canada.
Department of Genetics, Cell Biology and Development, Stem Cell Institute, University of Minnesota, Minneapolis, MN, USA.
出版信息
Wiley Interdiscip Rev Dev Biol. 2017 Jul;6(4). doi: 10.1002/wdev.270. Epub 2017 Mar 20.
Abstract
Functional annotation of mutations that cause human limb anomalies is enabled by basic developmental studies. In this study, we focus on the prepatterning stage of limb development and discuss a recent model that proposes anterior and posterior domains of the early limb bud generate two halves of the future skeleton. By comparing phenotypes in humans with those in model organisms, we evaluate whether this prepatterning concept helps to annotate human disease alleles. WIREs Dev Biol 2017, 6:e270. doi: 10.1002/wdev.270 For further resources related to this article, please visit the WIREs website.
摘要
基础发育研究实现了对导致人类肢体异常的突变的功能注释。在本研究中，我们聚焦于肢体发育的预模式阶段，并讨论一种近期的模型，该模型提出早期肢芽的前后区域会生成未来骨骼的两半。通过比较人类与模式生物的表型，我们评估这种预模式概念是否有助于注释人类疾病等位基因。《WIREs发育生物学》2017年第6期，e270。doi:10.1002/wdev.270 有关本文的更多资源，请访问WIREs网站。
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